D. TanphaichitraS. SrimuangMahidol University2018-06-142018-06-141988-12-01Drugs under Experimental and Clinical Research. Vol.14, No.8 (1988), 529-531037865012-s2.0-0024227114https://repository.li.mahidol.ac.th/handle/123456789/15488During 1984 to 1988, 35 patients with urinary tract infction (UTI) and 37 patients with enteric fever were treated successfully with 400 mg ofloxacin twice a day for 7 to 10 days. Clinical cure or improvement was observed in 31 of the 35 patients with UTI; 32 patients were bacteriologically assessed and eradication was achieved in all of them. Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyhi A subsequently died, due to his underlying disorder. The MIC 90 of the Enterobacteriaceae including Salmonella was less than 0.12 μg/ml. Interestingly, β-lactamase-producing strains of Salmonella and other Enterobacteriaceae in the present study were 28% and 29%, respectively. Ofloxacin therefore offers an effective b.i.d. dosage schedule for enteric fever and UTI due to β-lactamase-producing bacteria.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS