Sathitakorn O.Jantarathaneewat K.Weber D.J.Warren D.K.Nanthapisal S.Rutjanawech S.Apisarnthanarak P.Apisarnthanarak A.Mahidol University2023-06-182023-06-182022-05-01American Journal of Infection Control Vol.50 No.5 (2022) , 581-58401966553https://repository.li.mahidol.ac.th/handle/123456789/85931Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the “Clinical Pulmonary for Infection Score” (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P <.01). Compared to “non PCT-CPIS” group, “PCT-CPIS” group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P =.03), shorter antibiotic duration (2 days vs 7 days; P <.01) and length of hospital stay (10 days vs 16 days; P <.01).MedicineArticleSCOPUS10.1016/j.ajic.2022.01.0302-s2.0-851273557251527329635158008