Kiyoshi KikuchiKo ichi KawaharaKamal Krishna BiswasTakashi ItoSalunya TancharoenNaoto ShiomiYoshiro KodaFumiyo MatsudaYoko MorimotoYoko OyamaKazunori TakenouchiNaoki MiuraNoboru ArimuraYuko NawaShinichiro ArimuraMeng Xiao JieBinita ShresthaMasahiro IwataKentaro MeraHisayo SameshimaYoshiko OhnoRyuichi MaenosonoYutaka TajimaHisaaki UchikadoTerukazu KuramotoKenji NakayamaMinoru ShigemoriYoshihiro YoshidaTeruto HashiguchiIkuro MaruyamaDivision of Laboratory and Vascular MedicineKagoshima University Faculty of MedicineKagoshima UniversityOmuta City General HospitalSaiseikai Shiga HospitalKurume University School of MedicineMahidol University2018-09-242018-09-242010-01-01Experimental and Therapeutic Medicine. Vol.1, No.1 (2010), 109-11117921015179209812-s2.0-77955784283https://repository.li.mahidol.ac.th/handle/123456789/28848Estimation of the postmortem interval (PMIPMIPMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMHMGB1), a nonhistone DNADNADNA-binding protein is released by eukaryotic cells upon necrosis. Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4, 14 and 24 °C since death were measured by enzyme-linked immunosorbent assay. The serum HMHMGB1 level showed a time-dependent increase up to seven days at 4 °C. At 14 °C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued. At 24 °C, the HMHMGB1 level peaked at day 2, decreased at day 3, and then plateaued. Our findings suggest that HMGB1 is related to the PMIPMIPMI in rats.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyArticleSCOPUS10.3892/etm_00000019