Niklas LindegardhGeraint R. DaviesTran Tinh HienJeremy FarrarPratap SinehasivanonNicholas P J DayNicholas J. WhiteMahidol UniversityNuffield Department of Clinical MedicineUniversity of LiverpoolUCL2018-08-202018-08-202006-09-01Antimicrobial Agents and Chemotherapy. Vol.50, No.9 (2006), 3197-3199006648042-s2.0-33748685657https://repository.li.mahidol.ac.th/handle/20.500.14594/23636The anti-influenza drug oseltamivir is an ester prod rug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes. Copyright © 2006, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicineArticleSCOPUS10.1128/AAC.00500-06