Makanga, MichaelSrivicha Krudsoodศรีวิชา ครุฑสูตรMahidol University. Faculty of Tropical Medicine. WHO CC for Clinical Management of Malaria2012-12-182016-09-292012-12-182016-09-2920092012-12-182009-10-12Makanga M, Krudsood S. The clinical efficacy of artemether/lumefantrine (Coartem). Malar J. 2009 Oct 12;8 Suppl 1:S5.1475-2875 (electronic)https://repository.li.mahidol.ac.th/handle/20.500.14594/737Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT prequalified by the WHO for efficacy, safety and quality, approved by Swissmedic in December 2008 and recently approved by the USA FDA. Coartem is a fixed-dose combination of artemether and lumefantrine. Its two components have different modes of action that provide synergistic anti-malarial activity. It is indicated for the treatment of infants, children and adults with acute, uncomplicated infection due to Plasmodium falciparum or mixed infections including P. falciparum. A formulation with improved palatability has been developed especially for children (Coartem Dispersible), which rapidly disperses in a small amount of water for ease of administration. The efficacy of the six-dose regimen of artemether/lumefantrine has been confirmed in many different patient populations around the world, consistently achieving 28-day PCR (polymerase chain reaction)-corrected cure rates of >95% in the evaluable population, rapidly clearing parasitaemia and fever, and demonstrating a significant gametocidal effect, even in areas of widespread parasite resistance to other antimalarials.engMahidol UniversityAntimalarialsArtemisininsDrug combinationsPolymerase chain reactionOpen Access articleResearch ArticleBioMed Central10.1186/1475-2875-8-S1-S5