Kamboonsri N.Sriwaranon T.Tantisereepatana N.Puncreobutr C.Lohwongwatana B.Olson G.B.Tel A.Robiony M.Achakulvisut T.Vateekul P.Mahidol University2026-06-212026-06-212026-01-01IEEE Access (2026)https://repository.li.mahidol.ac.th/handle/123456789/117444Virtual surgical planning (VSP) is essential step in mandible reconstruction, involving multiple tasks, such as structure segmentation, cutting-plane definition, and implant planning. While many studies have shown promising results on subtasks using specialized ML models, these models are typically developed in isolation. This fragmentation prevents their seamless integration into a unified, automated clinical pipeline. We present a fully automated VSP assistant integrated into 3D Slicer combining segmentation, reconstruction, and planning modules into a single clinical framework. The proposed pipeline was validated on real clinical datasets, including unhealthy mandible dataset containing mandible abnormalities, healthy mandible dataset with normal mandible, and fibula dataset of normal fibula. Quantitative evaluation using the dice similarity coefficient (DSC) yielded scores of 0.911 for mandible segmentation, 0.854 for defect segmentation, 0.908 for fibula segmentation, and 0.816 for mandible reconstruction. Planning module reduced average operation time by 57% while maintaining accuracy comparable to manual planning. End-to-end evaluation on real clinical cases demonstrated a dramatic reduction in the total time engineer spent completing tasks from average of 5 hours 21 minutes using the manual workflow to 29 minutes 38 seconds. Our results demonstrate that automated VSP offers a practical, clinically precise solution that reduces the time-intensive nature of VSP, bridging the gap between isolated ML research and real-world surgical practice.Materials ScienceComputer ScienceEngineeringArticleSCOPUS10.1109/ACCESS.2026.37023272-s2.0-10504182178021693536