Momoko HorikoshiHanieh YaghootkarDennis O. Mook-KanamoriUlla SovioH. Rob TaalBranwen J. HennigJonathan P. BradfieldBeate St PourcainDavid M. EvansPimphen CharoenMarika KaakinenDiana L. CousminerTerho LehtimäkiEskil Kreiner-MøllerNicole M. WarringtonMariona BustamanteBjarke FeenstraDiane J. BerryElisabeth ThieringThiemo PfabSheila J. BartonBeverley M. ShieldsMarjan KerkhofElisabeth M. Van LeeuwenAnthony J. FulfordZoltán KutalikJing Hua ZhaoMarcel Den HoedAnubha MahajanVirpi LindiLiang Kee GohJouke Jan HottengaYing WuOlli T. RaitakariMarie N. HarderAline MeirhaegheIoanna NtallaRany M. SalemKaren A. JamesonKaixin ZhouDorota M. MoniesVasiliki LagouMirna KirinJani HeikkinenLinda S. AdairFowzan S. AlkurayaAli Al-OdaibPhilippe AmouyelEhm Astrid AnderssonAmanda J. BennettAlexandra I.F. BlakemoreJessica L. BuxtonJean DallongevilleShikta DasEco J.C. De GeusXavier EstivillClaudia FlexederPhilippe FroguelFrank GellerUniversity of OxfordWellcome Trust Centre for Human GeneticsUniversity of ExeterErasmus University Medical CenterWeill Cornell Medicine-QatarImperial College LondonLondon School of Hygiene & Tropical MedicineMedical Research CouncilMedical Research Council Laboratories GambiaThe Children's Hospital of PhiladelphiaUniversity of BristolMahidol UniversityOulun YliopistoHelsingin YliopistoTampereen YliopistoUniversity Hospital of TampereUniversity of Copenhagen, Faculty of Health SciencesCopenhagen University HospitalUniversity of Western Australia Faculty of Medicine and DentistryCentre de Recerca en Epidemiologia Ambiental, BarcelonaHospital del MarCIBER Epidemiologia Y Salud PublicaCentro de Regulacion GenomicaStatens Serum InstitutUCL Institute of Child HealthHelmholtz Center Munich German Research Center for Environmental HealthCharité – Universitätsmedizin BerlinUniversitat PotsdamUniversity of SouthamptonUniversity of Groningen, University Medical Center GroningenUniversitat Lausanne SchweizSwiss Institute of BioinformaticsAddenbrooke's HospitalIta-Suomen yliopistoDuke-NUS Graduate Medical School SingaporeNational University of SingaporeVrije Universiteit AmsterdamThe University of North Carolina at Chapel HillTurun yliopistoInsermInstitut Pasteur LilleUniversity of LilleUniversite Lille 2 Droit et SanteHarokopio UniversityChildren's Hospital BostonBroad InstituteHarvard Medical SchoolUniversity of DundeeKing Faisal Specialist Hospital and Research CentreUniversity of EdinburghKing Khaled Eye Specialist HospitalAlfaisal UniversityUniversitat Pompeu FabraHammersmith HospitalSouthampton University Hospitals NHS TrustLille Inflammation Research International CenterFaculty of Health Sciences, University of Southern DenmarkCentre for Medical Systems BiologyAmtssygehuset i GlostrupKobenhavns UniversitetUniversity of Athens Medical SchoolUniversitat LeipzigMedizinische Hochschule Hannover (MHH)Northwestern UniversityUniversity of GroningenKlinikum der Universitat MunchenRigshospitaletSteno Diabetes Center2018-10-192018-10-192013-01-01Nature Genetics. Vol.45, No.1 (2013), 76-8215461718106140362-s2.0-84871987100https://repository.li.mahidol.ac.th/handle/20.500.14594/31430Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1038/ng.2477