S. KrishnaS. PukrittayakameeW. SupanaranondF. ter KuileM. RuprahT. SuraN. J. WhiteMahidol UniversityJohn Radcliffe HospitalPoisons UnitRamathipodi Hospital2018-07-042018-07-041995-01-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.89, No.5 (1995), 507-50918783503003592032-s2.0-0028807961https://repository.li.mahidol.ac.th/handle/20.500.14594/17327Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-‘blind’ study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use. © 1995 Oxford University Press.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/0035-9203(95)90087-X