Synthesis of alkylated indolizidine alkaloids via Pummerer mediated cyclization: synthesis of (±)-indolizidine 167B, (±)-5-butylindolizidine and (±)-monomorine I

Chutima KuhakarnPhachanee SeehasombatThaworn JaipetchManat PohmakotrVichai ReutrakulMahidol University2018-07-122018-07-122008-02-18Tetrahedron. Vol.64, No.8 (2008), 1663-1670004040202-s2.0-38349057328https://repository.li.mahidol.ac.th/handle/20.500.14594/18969The syntheses of indolizidine alkaloids, i.e., (±)-coniceine, (±)-indolizidine 167B, (±)-5-butylindolizidine and (±)-monomorine I via Pummerer cyclization are described. The key step is the transformation of lactam sulfoxide to bicyclic lactam via the Pummerer cyclization. © 2007 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsSynthesis of alkylated indolizidine alkaloids via Pummerer mediated cyclization: synthesis of (±)-indolizidine 167B, (±)-5-butylindolizidine and (±)-monomorine IArticleSCOPUS10.1016/j.tet.2007.12.013