S. BoonpucknavigJ. SiripontMahidol University2018-04-302018-04-301980-01-01Clinical and Experimental Immunology. Vol.39, No.3 (1980), 676-682000991042-s2.0-0018876969https://repository.li.mahidol.ac.th/handle/20.500.14594/11108Preformed soluble dengue antigen-antibody with or without complement complexes could bind to the surface of human lymphocytes via IgG (Fc) or complement receptors respectively. It may be that these lymphocytes were B lymphocytes not T lymphocytes. Dengue antigen or antibody alone will not attach to the surface of those cells. It is emphasized that dengue antigen-antibody complexes can form in the circulation and some will bind to the surface of the B lymphocytes in vivo and play a significant role in the pathogenesis of dengue haemorrhagic fever. In addition mice could develop glomerulonephritis by injection with preformed soluble dengue antigen-antibody complexes. These mice showed proteinuria and deposits of the immune complexes in the glomeruli of the kidneys.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS