Efficient synthesis of 2H-chromene derivatives via a dual-organocatalytic reaction

Siriphong SomprasongWatcharapon PrasitwatcharakornTorsak LuanphaisarnnontMahidol University2020-10-052020-10-052020-10-15Tetrahedron Letters. Vol.61, No.42 (2020)18733581004040392-s2.0-85090718573https://repository.li.mahidol.ac.th/handle/20.500.14594/58946© 2020 Elsevier Ltd An efficient synthetic method was developed for the selective construction of 2H-chromene derivatives from various salicylaldehydes and acetylenic diesters using a dual catalyst system (p-toluenesulfonic acid monohydrate and pyrrolidine). The advantages of this transformation include high selectivity, good functional group tolerance, operational simplicity, and mild reaction conditions.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryEfficient synthesis of 2H-chromene derivatives via a dual-organocatalytic reactionArticleSCOPUS10.1016/j.tetlet.2020.152402