Boonyapratheeprat N.Pimolbutr K.Rungraungrayabkul D.Meenetkum S.Boongird S.Chuengsaman P.Okuma N.Thanakun S.Kitiyakara C.Sangkhamanee S.S.Mahidol University2025-04-032025-04-032025-01-01European Journal of Dentistry (2025)13057456https://repository.li.mahidol.ac.th/handle/123456789/109302Objectives ?This cross-sectional study aimed to investigate the oral health-related quality of life (OHRQoL), its associated factors, and the prevalence of possible sarcopenia in Thai well-maintained patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD). Materials and Methods ?Data were collected from 63 participants undergoing PD at Banphaeo-Charoenkrung Hemodialysis Center. Dry mouth was evaluated through unstimulated salivary flow rate measurement and self-reported xerostomia questionnaires. OHRQoL was assessed using the Thai version of Oral Health Impact Profile (OHIP-14). Statistical Analysis ?Statistical analyses were conducted using IBM SPSS Statistics version 21.0. Descriptive statistics summarized participant characteristics, and normality was tested with the Kolmogorov-Smirnov test. Continuous variables were expressed as medians and interquartile ranges, while categorical variables were presented as frequencies and percentages. The Mann-Whitney U test and Fisher's exact test were used to assess differences between OHRQoL groups. Partial Spearman's rank correlation examined variable relationships, and logistic regression identified factors linked to a higher negative impact on OHRQoL, adjusting for age, sex, body mass index, chair stand test, and salivary flow rate. A p -value of < 0.05 was considered significant. Results ?The median age was 59 years (range 27-79), with a possible sarcopenia prevalence of 52.4%. OHIP-14 scores ranged from 0 to 32, with medians of 4 and 13 in a lower (n = 31) and higher (n = 32) negative impact on OHRQoL, respectively. Those with a higher negative impact on OHRQoL exhibited a significantly higher proportion of self-reported xerostomia (p = 0.01), lower salivary flow rate (p = 0.01), and longer 5-time chair stand test (p = 0.04) compared to individuals with the lower negative impact on OHRQoL. Correlation between the time of the chair stand test and the handgrip strength adjusting for age (r = -0.439, p < 0.001) and sex (r = -0.351, p = 0.006) was revealed. Multivariate logistic regression showed a significant association between salivary flow rate and a higher negative impact on OHRQoL (odds ratio 0.018; 95% confidence interval: 0.001, 0.545; p = 0.02). Conclusion ?This finding suggests that reduced salivary flow affected OHRQoL in well-maintained ESRD patients with PD, highlighting the importance of managing dry mouth to alleviate their OHRQoL.DentistryArticleSCOPUS10.1055/s-0045-18025672-s2.0-10500029320513057464