Pichit SudtaPayung JiarawapiApichart SuksamrarnPoonpilas HongmaneeSunit SuksamrarnSrinakharinwirot UniversityRamkhamhaeng UniversityMahidol University2018-10-192018-10-192013-02-01Chemical and Pharmaceutical Bulletin. Vol.61, No.2 (2013), 194-20313475223000923632-s2.0-84873593744https://repository.li.mahidol.ac.th/handle/20.500.14594/31554A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan.Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1248/cpb.c12-00874