Robert ParisSasitorn BejrachandraPrasert ThongcharoenSorachai NitayaphanPunnee PitisuttithumAnna SamborSanjay GurunathanDonald FrancisSilvia Ratto-KimChitraporn KarnasutaMark S. de SouzaVictoria R. PolonisArthur E. BrownJerome H. KimHenry A. StephensArmed Forces Research Institute of Medical Sciences, ThailandFaculty of Medicine, Siriraj Hospital, Mahidol UniversityMahidol UniversityUnited States Military HIV Research Program/Henry M. Jackson FoundationSanofi PasteurGlobal Solutions for Infectious DiseasesWalter Reed Army Institute of ResearchUCL2018-06-112018-06-112012-01-20Vaccine. Vol.30, No.5 (2012), 832-836187325180264410X2-s2.0-84855439087https://repository.li.mahidol.ac.th/handle/20.500.14594/13823Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE. Non-response to vaccine associated with DRB1*11 (3/32 responders vs. 7/13 non-responders, p c =0.027) and DRB1*16:02 (0/32 responders vs. 4/13 non-responders, p c =0.078) alleles. Furthermore, vaccine recipients with HLA-DQ heterodimers encoded by DQA1*05:01 and DQB1*03:01 alleles, were much less likely to produce NAb (p=0.009). These data suggest that the lack of response to a vaccine designed to induce clade-specific NAb to HIV-1 is associated with the presence of certain HLA class II alleles and heterodimers in some Southeast Asians. © 2011.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineVeterinaryArticleSCOPUS10.1016/j.vaccine.2011.11.002