Kok Ann GweeWarren Wei Rhen LeeKhoon Lin LingChoon Jin OoiSeng Hock QuakYock Young DanKewin Tien Ho SiahJames Guoxian HuangAndrew Seng Boon ChuaIda Normiha HilmiRaja Affendi Raja AliChristina OngMarcellus SimadibrataMurdani AbdullahJose D. SollanoSomchai LeelakusolvongSutep GonlachanvitYeong Yeh LeeJane D. Ricaforte-CamposYee Kian YinKuck Meng ChongChong Yuen WongDe La Salle Health Sciences InstituteNational University Health SystemDuke-NUS Medical School SingaporeUniversity of Santo Tomas HospitalUniversity of Indonesia, RSUPN Dr. Cipto MangunkusumoUniversity of MalayaChulalongkorn UniversityYong Loo Lin School of MedicineKK Women's And Children's HospitalFaculty of Medicine, Siriraj Hospital, Mahidol UniversityGleneagles HospitalSchool of Medical Sciences - Universiti Sains MalaysiaUniversiti Kebangsaan MalaysiaKlinik Pakar Y&CKlnic ChongKK HospitalIpoh Gastro CentreFatimah HospitalGeneral Hospital2019-08-232019-08-232018-10-01Journal of Gastroenterology and Hepatology (Australia). Vol.33, No.10 (2018), 1707-171614401746081593192-s2.0-85052825627https://repository.li.mahidol.ac.th/handle/123456789/46313© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd The concept of consuming microorganisms in the treatment of a medical condition and in health maintenance has gained much attraction, giving rise to an abundance of medical claims and of health supplements. This study identified relevant clinical questions on the therapeutic use of probiotics and reviewed the literature in irritable bowel syndrome, inflammatory bowel disease, impaired intestinal immunity, liver disease, intestinal infections, and common childhood digestive disorders. Statements were developed to address these clinical questions. A panel of experienced clinicians was tasked to critically evaluate and debate the available data. Both consensus and contentious statements are presented to provide to clinicians a perspective on the potential of probiotics and importantly their limitations.Mahidol UniversityMedicineReviewSCOPUS10.1111/jgh.14268