Nelson LeeChun Kwok WongPaul K.S. ChanNiklas LindegardhNicholas J. WhiteFrederick G. HaydenEdward H.C. WongKa Shing WongClive S. CockramJoseph J.Y. SungDavid S.C. HuiChinese University of Hong KongMahidol UniversityUniversity of OxfordUniversity of Virginia Medical School2018-09-242018-09-242010-01-01Emerging Infectious Diseases. Vol.16, No.1 (2010), 139-14210806059108060402-s2.0-73949099692https://repository.li.mahidol.ac.th/handle/20.500.14594/29877We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios >3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.Mahidol UniversityMedicineArticleSCOPUS10.3201/eid1601.090007