Juno OhashiI. NakaJ. PatarapotikulH. HananantachaiS. LooareesuwanK. TokunagaUniversity of TokyoMahidol University2018-07-242018-07-242003-10-01Genes and Immunity. Vol.4, No.7 (2003), 528-531146648792-s2.0-3242745930https://repository.li.mahidol.ac.th/handle/20.500.14594/20689We examined possible association of single-nucleotide polymorphisms (SNPs) in the promoters of IL-3, IL-4, and IL- 13 genes on the 5q31-33, IL-3 - 16T> C, IL-4 - 590T> C, and IL-13 - 1055C> T, with severity of malaria in 361 adult malaria patients in Thailand. The IL-13 - 1055T allele showed a significant association with protection from severe malaria (OR 0.51, 95% CI 0.32-0.80; P= 0.0032 by the χ2test), while allele frequencies of IL-3 - 16T> C and IL-4 -590T> C were not statistically different between mild and severe malaria patients. An IL-13 - 1055C> T has been reported to alter the regulation of IL-13 production. Thus, IL-13 - 1055T may show resistance to severe malaria through the alteration of IL-13 production. © 2003 Nature Publishing Group All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyArticleSCOPUS10.1038/sj.gene.6364010