S. PootrakulS. AssawamunkongS. Na-NakornMahidol University2018-04-192018-04-191976-01-01Hemoglobin. Vol.1, No.1 (1976), 75-83036302692-s2.0-0017211107https://repository.li.mahidol.ac.th/handle/20.500.14594/10845In Thailand, two types of high 1% A 2 -B-thalassemia genes: β O -thalassemia (β O -thal) or classical βthalnssemia and β + -thalassemia (β + -thal) or mild 6-thalasseinin exist. This study presents hematologic data and globin chain synthesis in peripheral blood of the genuine β + -thal hetcrozygotes in comparision with those of the β O -thal heterozygotes. Thirty individuals of Thai and Chinese exctraction with the β + -thal heterozygosity were hematologically examined. The hematologic means of hemoglobin concentration, MLV, MCH, MCHC, 11h A 2 and alkali 3 denaturation hemoglobin of the β + -thal traits were, 11.7 g% 67.8 u 3 , 21.5 γgamma; 32.1% 4.94% and 1.20% respectively. These were not statistically different from those of the β O -thal traits of our previous study(1). The globin chin synthesis in reticulocytes were performed by incorporation of 3 H-Leucine for 3 hours. The mean of total radioactivity αbeta; ratio in 11 normal controls was 1.07 ± SD 0.03 The mean of αbeta; ratio in 9 β + -thal traits was 2.03 ± SD 0.10 which was significantly different from that in 7 β O -thal traits of 2.28 ± SD 0.07 Our globin chain synthesis thus appears to be helpful of discriminating the β + -thal trait from the β O -thal trait. © 1976 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.3109/03630267609031023