A. Wilder-SmithA. LoverP. KittayapongG. BurnhamNational University of SingaporeMahidol UniversityJohns Hopkins University2018-05-032018-05-032011-06-01Medical Hypotheses. Vol.76, No.6 (2011), 861-862030698772-s2.0-79955733073https://repository.li.mahidol.ac.th/handle/20.500.14594/12487Dengue infection causes a significant economic, social and medical burden in affected populations in over 100 countries in the tropics and sub-tropics. Current dengue control efforts have generally focused on vector control but have not shown major impact. School-aged children are especially vulnerable to infection, due to sustained human-vector-human transmission in the close proximity environments of schools. Infection in children has a higher rate of complications, including dengue hemorrhagic fever and shock syndromes, than infections in adults. There is an urgent need for integrated and complementary population-based strategies to protect vulnerable children. We hypothesize that insecticide-treated school uniforms will reduce the incidence of dengue in school-aged children. The hypothesis would need to be tested in a community based randomized trial. If proven to be true, insecticide-treated school uniforms would be a cost-effective and scalable community based strategy to reduce the burden of dengue in children. © 2011 Elsevier Ltd.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.mehy.2011.02.037