Noriko SakamotoYukihiro AkedaYo SugawaraDan TakeuchiDaisuke MotookaNorihisa YamamotoWarawut LaolerdPitak SantanirandShigeyuki HamadaOsaka UniversityHandai ByoinFaculty of Medicine, Ramathibodi Hospital, Mahidol University2019-08-232019-08-232018-12-01Antimicrobial Agents and Chemotherapy. Vol.62, No.12 (2018)10986596006648042-s2.0-85057185517https://repository.li.mahidol.ac.th/handle/20.500.14594/46157© 2018 American Society for Microbiology. All Rights Reserved. We report here Klebsiella pneumoniae strains carrying chromosomal bla NDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing bla NDM-1 , which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of bla NDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1128/AAC.01520-18