Witaya ThamavitPakasit PratoomtoneSurapol KongtimTomoyuki ShiraiNobuyuki ItoMahidol UniversityNagoya City University2018-09-072018-09-072001-01-01Asian Pacific Journal of Cancer Prevention. Vol.2, No.1 (2001), 69-702476762X151373682-s2.0-84873488645https://repository.li.mahidol.ac.th/handle/20.500.14594/26484The present experiment was conducted to assess the influence of vitamin E, given in the diet at 0.5 or 1%, on induction of lesions in the Syrian hamster liver by long term combined administration of sodium nitrite and aminopyrine in the drinking water. Inhibition of both cholangiofibrosis and cholangiocarcinoma development, as well as a reduction in hepatocellular nodules was the result. The underlying mechanisms presumably involve alteration of endogenous dimethylnitrosamine formation by the vitamin, with clear implications for prevention in the human environment.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS