Aranya JutiviboonsukHong Jie ZhangTamara P. KondratyukAngkana HerunsaleeWongsatit ChaukulJohn M. PezzutoHarry H.S. FongNuntavan BunyapraphatsaraMahidol UniversityUniversity of Illinois at ChicagoPurdue UniversityThailand Ministry of Public Health2018-08-242018-08-242007-03-01Pharmaceutical Biology. Vol.45, No.3 (2007), 185-19417445116138802092-s2.0-34247584005https://repository.li.mahidol.ac.th/handle/20.500.14594/24243A new plant species, Barringtonia maunwongyathiae W. Chuakul (Lecythidaceae), was recently discovered in Khuan Thon Forest, Ao Luek District, Krabi Province, Thailand. Chemical investigation of the leaves of this plant led to the isolation of 10 triterpenes, 3 steroids, and a vitamin E derivative. The structures of these compounds were identified as taraxerol (1), 3-(E)-coumaroyltaraxerol (2), 3-(Z)-coumaroyltaraxerol (3), 3-(E)-coumaroyl β-amyrin (4), 3-(Z)-coumaroyl β-amyrin (5), 3-(E)-coumaroyl α-amyrin (6), 3-(Z)-coumaroyl α-amyrin (7), 3-(E)-coumaroyllupeol (8), 3-(Z)-coumaroyllupeol (9), 3,19,24-trihydroxyurs-12-ene-28-oic acid (10), stigma-4,22-dien-3-one (11), β-stigmasterol (12), 3-O-β-D- glucopyranosyl-stigmasta-5,22-diene (13), and α-tocopherylquinone (14). All compounds were evaluated for their cancer chemopreventive potential based on inhibition of TPA-induced ornithine decarboxylase expression, COX-1 and COX-2 activities, and phorbol ester-induced NF-κB luciferase expression, as well as activation of antioxidant response element-mediated luciferase expression. Compounds 1, 2, and 14 demonstrated greatest promise, while 12 and 13 showed moderate activity. © 2007 Informa Healthcare.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1080/13880200701213062