Nicholas J. WhiteGareth D.H. TurnerNicholas P.J. DayArjen M. DondorpMahidol UniversityUniversity of Oxford2018-10-192018-10-192013-07-15Journal of Infectious Diseases. Vol.208, No.2 (2013), 192-198002218992-s2.0-84879331864https://repository.li.mahidol.ac.th/handle/20.500.14594/32259One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right. © 2013 The Author 2013. Published by Oxford University Press on behalf of the Infectious Disease Society of America.Mahidol UniversityMedicineReviewSCOPUS10.1093/infdis/jit116