Eun Kyoung SeoHeebyung ChaiHoward L. ConstantThawatchai SantisukVichai ReutrakulChristopher W W BeecherNorman R. FarnsworthGeoffrey A. CordellJohn M. PezzutoA. Douglas KinghornUniversity of Illinois at ChicagoThe Forest Herbarium, Thailand Ministry of Natural Resources and EnvironmentMahidol UniversityRTI InternationalBristol-Myers Squibb2018-09-072018-09-071999-09-17Journal of Organic Chemistry. Vol.64, No.19 (1999), 6976-6983002232632-s2.0-0033578950https://repository.li.mahidol.ac.th/handle/20.500.14594/25379Vatdiospyroidol (1), a novel cytotoxic resveratrol tetramer, was isolated from the stems of Vatica diospyroides Sym. (Dipterocarpaceae) by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Another novel resveratrol tetramer, vaticaphenol A (2), was obtained as a noncytotoxic constituent, along with the known compounds, bergenin, betulin, betulinic acid, mangiferonic acid, and (E)- resveratrol 3-O-β-D-glucopyranoside. The structures of compounds 1 and 2 were elucidated by spectral analysis, including 1D and 2D NMR experiments, and by molecular modeling.Mahidol UniversityChemistryArticleSCOPUS10.1021/jo9902087