Promrug D.Arthan D.Thongyoo P.Mahidol University2024-08-052024-08-052024-10-01Microchemical Journal Vol.205 (2024)0026265Xhttps://repository.li.mahidol.ac.th/handle/20.500.14594/100261A novel responsive fluorescent sensor derived from a fluorescein framework has been successfully fabricated for highly selective dual recognition of Cr3+ and H2S in aqueous solution. Bisanthraflu demonstrated excellent selectivity and great sensitivity towards Cr3+ with a non-fluorescent complex of bisanthraflu-Cr3+ formation via a 2:1 binding mode with minimum detectable amount of 1.7 μM. The fluorescent intensity of the bisanthraflu-Cr3+ complex was markedly restored in the presence of H2S via the displacement approach, potentially applicable as a highly responsive probe for H2S detection with a low detectable concentration of 1.95 μM. This dual functional fluorescent sensor with an On-Off-On approach demonstrated potential for detecting H2S in live HeLa cells with not significant cytotoxicity.ChemistryArticleSCOPUS10.1016/j.microc.2024.1113232-s2.0-85199960489