Li HuangMonroe E. WallMansukh C. WaniHernán NavarroThawatchai SantisukVichai ReutrakulEun Kyoung SeoNorman R. FarnsworthA. Douglas KinghornRTI InternationalThe Forest Herbarium, Thailand Ministry of Natural Resources and EnvironmentMahidol UniversityUniversity of Illinois at Chicago2018-07-042018-07-041998-04-01Journal of Natural Products. Vol.61, No.4 (1998), 446-450016338642-s2.0-0031957885https://repository.li.mahidol.ac.th/handle/20.500.14594/18308Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays. Compounds 2-5 have not been reported previously, while 1 is new as a natural product. Structural assignments were made based on extensive spectroscopic measurements. Compounds 1-3 were inactive in the 9KB cytotoxicity assay, with compounds 4 and 5 having weak activity. In the DNA strand-scission assay, 3 was the most active compound found in the DNA strand-scission assay, being 10 times more potent than 1 or 2. Compound 4 was only weakly active, and 5 was inactive.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np9703609