Pichit TosukhowongThararat SupasiriMahidol University2018-10-122018-10-121985-01-01Journal of Labelled Compounds and Radiopharmaceuticals. Vol.22, No.9 (1985), 925-93010991344036248032-s2.0-0021829501https://repository.li.mahidol.ac.th/handle/20.500.14594/30754[4‐3H]‐Dehydroretinol (5) was prepared from a vitamin A derivative. The procedure involves conversion of methyl retinoate (1) to methyl 4‐oxoretinoate (2) by manganes dioxide oxidation. The 3H‐label was introduced by sodium borotritide reduction of methyl 4‐oxoretinoate (2) followed by acid catalyzed dehyration to methyl [4‐3H]‐3‐dehydroretinoate (4). Reduction of the tritiated methyl dehydroretinoate with lithium aluminium hydride yielded [4‐3H]‐3‐dehydroretinol (5). Final purification was achieved by preparative thin layer chromatography. Copyright © 1985 John Wiley & Sons, Ltd.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1002/jlcr.2580220908