Joshua ParksThinley GyeltshenVilailak PrachyawarakornChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteUniversity of PortlandChulabhorn Graduate InstituteMahidol University2018-09-242018-09-242010-05-28Journal of Natural Products. Vol.73, No.5 (2010), 992-99415206025016338642-s2.0-77952974771https://repository.li.mahidol.ac.th/handle/20.500.14594/28706Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia. © 2010 The American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np100078s