Jonathan WeberEva Maria FenyöSimon BeddowsPontiano KaleebuÅsa BjörndalS. OsmanovW. HeywardJ. EsparzaB. Galvao-CastroP. Van De PerreE. KaritaC. WasiS. SempalaB. TugumeB. BiryahwahoH. Rübsamen-WaigmannH. Von BriesenR. EsserM. GrezH. HolmesA. NewberryS. RanjharP. TomlinsonJ. BradacImperial College LondonKarolinska InstitutetUNAIDSFundacao Oswaldo CruzNational Reference LaboratoryMahidol UniversityUganda Virus Research InstituteGeorg-Speyer-HausNational Institute for Biological Standards and ControlNational Institute of Allergy and Infectious Diseases2018-07-042018-07-041996-11-01Journal of Virology. Vol.70, No.11 (1996), 7827-78320022538X2-s2.0-10244249213https://repository.li.mahidol.ac.th/handle/20.500.14594/17515Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype- specific neutralization was observed. Most plasma tested were broadly cross- neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.Mahidol UniversityAgricultural and Biological SciencesImmunology and MicrobiologyArticleSCOPUS