David A. SchwartzSuthi SungkaratNathan ShafferJirasak LaosakkitiboranWendy SupapolPichai CharoenpanichTuenjai ChuangsuwanichTimothy D. MastroEmory University School of MedicineMahidol UniversityCenters for Disease Control and PreventionHIV/AIDS Collaboration2018-09-072018-09-072000-01-01Journal of Infectious Diseases. Vol.182, No.6 (2000), 1788-1790002218992-s2.0-0033711560https://repository.li.mahidol.ac.th/handle/20.500.14594/26346The effects of human immunodeficiency virus (HIV) type 1 on the placenta and the role of the placenta in mother-to-child HIV-1 transmission are not well understood. Placentas from 78 HIV-infected and 158 HIV-uninfected women were examined as part of a prospective perinatal HIV transmission study in Bangkok. HIV-infected women were more likely than HIV-uninfected women to have chorioamnionitis (odds ratio [OR], 2.1; P = .03), placental membrane inflammation (PMI; OR, 2.7; P = .02), and deciduitis (OR, 2.3; P = .03) and less likely to have villitis (OR, 0.3; P = .02). However, among HIV-infected women, fewer women who transmitted infection to their child had chorioamnionitis (relative risk [RR], 0.2; P = .03), funisitis (RR, 0.4; P =. 1), or PMI (RR undefined; P = .03). These findings suggest that, in this population, HIV-infected women are at increased risk for placental membrane inflammatory lesions, but that placental inflammatory lesions are not associated with increased perinatal HIV transmission. © Oxford University Press 2001.Mahidol UniversityMedicineArticleSCOPUS10.1086/317598