Francis CapulePramote TragulpiankitSurakameth MahasirimongkolJiraphun JittikoonNuanjun WichukchindaLara Theresa Alentajan-AletaJay V.James BaritJosephine Casanova-GutierrezLeonor Cabral-LimJose Paciano Baltazar ReyesFrancisca RoaRaymark SalongaKatrina Faith San GabrielCatherine Lynn SilaoNational Institutes of Health, University of the Philippines ManilaUniversity of the Philippines ManilaUniversity of the East Ramon Magsaysay Memorial Medical CenterUniversity of the Philippines College of MedicineThailand Ministry of Public HealthMahidol University2022-08-042022-08-042021-06-01Pharmacogenomics. Vol.22, No.8 (2021), 465-47217448042146224162-s2.0-85107464545https://repository.li.mahidol.ac.th/handle/20.500.14594/76158Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.2217/pgs-2020-0191