K. AtisookR. PanyathanyaMahidol University2018-06-142018-06-141988-12-01The Southeast Asian journal of tropical medicine and public health. Vol.19, No.4 (1988), 637-642012515622-s2.0-0024257735https://repository.li.mahidol.ac.th/handle/20.500.14594/15605Autopsy findings of six cases of the acute systemic melioidosis from Siriraj Hospital, Bangkok, Thailand during the years 1977 to 1986 are presented. Five out of six cases had some underlying conditions. Multiple abscesses and multiple organs involvement were the rule. The organs most commonly involved were lung and liver. Three patients had pericardial and one had adrenal gland involvement. Other significant pathological findings were fibrin thrombi (5/6 cases), haemorrhage (6/6 cases), tissue necrosis (4/6 cases) and granular casts in renal tubules (1/6 case). Abscess alone cannot explain the death of patients. Toxaemia, both exotoxins and endotoxin, is the most likely explanation from the death of patients.Mahidol UniversityMedicineArticleSCOPUS