S. PhornchirasilpR. LockwoodMahidol University2018-03-222018-03-221977-01-01Archives Internationales de Pharmacodynamie et de Therapie. Vol.225, No.1 (1977), 98-103000397802-s2.0-0017326382https://repository.li.mahidol.ac.th/handle/123456789/10338Cyclic AMP levels were measured in cardiac and vascular tissues removed from pentobarbitone anesthetized rats pretreated with theophylline 45 mg/kg i.p. Noradrenaline, 20 μg/kg i.v., increased cardiac but not vascular cyclic AMP levels; this selective effect of noradrenaline was not altered by pretreatment with phenoxybenzamine, 1 mg/kg i.v. Tazolol, 120 μg/kg i.v., selectively increased cardiac cyclic AMP levels whereas fenoterol, 15 μg/kg i.v., selectively increased vascular cyclic AMP levels. The results suggest that adenylate cyclase activation in cardiac and vascular tissues in vivo is mediated by beta adrenoceptors which consist of different subtypes.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS