Bumroongsri P.Mahidol University2024-02-132024-02-132024-03-01Bioresource Technology Vol.395 (2024)09608524https://repository.li.mahidol.ac.th/handle/20.500.14594/97140Molasses is a by-product from sugarcane processing industries that contains some useful natural compounds. This paper proposes a method to produce sucralose, a non-caloric sweetener, from sugarcane molasses. In the first step, sugarcane molasses was converted to dried molasses powder using the low-temperature spray drying process in order to preserve natural compounds. Response surface methodology and artificial neural network were used to determine the experimental condition for maximal bioactive compounds content and antioxidant activity. Dried molasses powder could be produced with maximal values of sucrose yield, total phenolic content, total flavonoid content and antioxidant activity. In the final step, sucralose was derived from dried molasses powder. The yield of molasses-derived sucralose obtained from the proposed method was 0.628±0.01 g/g dried molasses powder with the purity of 99.95±0.02 %. The proposed method paves the way to convert sugarcane molasses to a non-caloric sweetener for applications in food and pharmaceutical industries.Chemical EngineeringEnergyEnvironmental ScienceArticleSCOPUS10.1016/j.biortech.2024.1303702-s2.0-851837477701873297638266787