Kriengsak LirdprapamongkolChulabhorn MahidolSanit ThongnestHunsa PrawatSomsak RuchirawatChantragan SrisomsapRudee SuraritPhaibul PunyaritJisnuson SvastiChulabhorn Research InstituteMahidol UniversityPhramongkutklao College of Medicine2018-07-242018-07-242003-01-01Journal of Ethnopharmacology. Vol.86, No.2-3 (2003), 253-256037887412-s2.0-0038301113https://repository.li.mahidol.ac.th/handle/20.500.14594/21038Metastasis, the spread of cancer in body, is a major cause of death. We have screened anti-metastatic activity of aqueous and dichloromethane extracts of several not previously studied Thai herbs, using an in vitro invasion test. This involves the in vitro invasion of HCC-S102, a hepatocellular carcinoma cell line derived from a Thai patient, through a reconstituted-basement membrane (Matrigel). The aqueous extract of a plant (Helixanthera parasitica) revealed a significant inhibitory effect on the cancer cell invasion, and showed antioxidant activity. The aqueous extract was partially purified by silica gel column chromatography, and the highest anti-metastatic activity fraction showed 83% inhibition of invasion with low cytotoxic effect. However, anti-metastatic activity was not associated with the antioxidant activity of the aqueous extract. © 2003 Elsevier Science Ireland Ltd. All rights reserved.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/S0378-8741(03)00072-2