Porntep ChomcheonSuthep WiyakruttaNongluksna SriubolmasNattaya NgamrojanavanichSurapong KengtongChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteChulalongkorn UniversityMahidol UniversityCenter for Environmental HealthThe Institute of Science and Technology for Research and Development, Mahidol University2018-09-132018-09-132009-02-01Phytochemistry. Vol.70, No.3 (2009), 407-413003194222-s2.0-62649168292https://repository.li.mahidol.ac.th/handle/123456789/27061Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50value of 5.30 μM. © 2009 Elsevier Ltd. All rights reserved.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.phytochem.2009.01.007