Sarut ChaisrisawadisukElie HammamCindy J. MolloyChristopher BarnettPeter J. AndersonMark H. MooreSiriraj HospitalFaculty of Health and Medical SciencesWomen's and Children's Hospital Adelaide2022-08-042022-08-042021-01-01Journal of Craniofacial Surgery. Vol.32, No.1 (2021), 261-26415363732104922752-s2.0-85099321871https://repository.li.mahidol.ac.th/handle/123456789/78857Cloverleaf skull deformity (CSD), or Kleeblattschädel, is a condition with severe and unpatterned multisuture craniosynostosis, resulting in a trilobar-shaped skull. This deformity mainly comprises a cranio-orbito-facial malformation that leads to a spectrum of multidisciplinary issues. Several syndromes are associated with CSD, such as Crouzon syndrome (CS). Here, we report the case of an infant with CS and the pathogenic c.1061C>G (p.Ser354Cys) variant of the fibroblast growth factor receptor 2 (FGFR2) gene. The child presented with the severe form of CSD despite having a normal, mid-trimester, sonographic scan.Mahidol UniversityMedicineArticleSCOPUS10.1097/SCS.0000000000006999