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Recent Submissions
Effects of Cutting Planes on Costal Cartilage Warping
(2025-01-01) Kiranantawat K.; Ratanapoompinyo S.; Kiranantawat K.; Mahidol University
Background Autogenous costal cartilage has become a favorable choice for nasal reconstruction and complicated aesthetic rhinoplasty because of its ample supply, sufficient for most patients. However, a notable drawback is the potential for warping. The authors’ study aims to identify cutting planes that minimize warping. Methods A total of 207 costal cartilage grafts were obtained by slicing the extracted costal cartilages from 10 fresh cadavers along 3 main planes: cephalocaudal, anteroposterior, and parallel to the synchondrosis plane. Each of these major planes was further divided into grafts taken from both the central and the peripheral portions. Furthermore, both subgroups were categorized into three thicknesses: 1, 2, and 3 mm. The warping angles of all grafts were then compared at various time intervals after the initial cutting. Results Cephalocaudal cuts exhibited significantly greater warping than other planes. Anteroposterior cuts displayed the least warping, although this difference lacked statistical significance. Peak warping occurred at 30 minutes. Certain grafts continued to warp even at 1 month. Central grafts had less warping than peripheral ones, although the difference was not statistically significant. Conclusions Cephalocaudal cuts yielded the highest warping angle. Surgeons seeking thin (<3 mm) straight grafts should opt for anteroposterior or parallel to synchondrosis planes. Thicker grafts (>3 mm) can be cut in the cephalocaudal plane with an acceptable warping angle, close to parallel with the synchondrosis plane. For curved cartilage, thin cephalocaudal cutting is recommended. In addition, the authors suggest placing the cartilage in normal saline for at least 30 minutes, allowing for maximum warping to occur.
Eating safely, eating Islam: Food hospitality and inter-ethnic relations in Muslim restaurants in Ningxia
(2025-09-01) Dorairajoo S.; Dorairajoo S.; Mahidol University
This article interrogates the relationship between food and faith in an instance of hospitality in halal restaurants in the autonomous Muslim province of Ningxia in north-western China. The non-Muslim Han Chinese majority here revealed an explicit preference for eating in halal restaurants owned and operated by the Hui-Muslim minority despite the fact that Han–Hui relations in daily life were at best cordial. Critiquing Derrida’s contention on the impossibility of absolute/unconditional hospitality, the author shows that absolute hospitality is indeed possible in the commercial encounter in halal restaurants in Ningxia as it is mediated by inter-ethnic prejudices and expectations. Hui and Han, bound by rules of hospitality, perform commensality in Hui restaurants primarily because of a Chinese nationwide concern with food safety. Rocked by numerous food scandals since the early 2000s, many non-Muslim Chinese looking for safe dining options have, in the case of Ningxia, resorted to dining in Muslim-run Hui restaurants. The belief that Hui would not knowingly taint their food as they serve fellow Muslims and are, therefore, bound by moral ethical-religious values to provide safe food makes Hui restaurants the preferred dining spaces for Chinese concerned with eating without fear.
Current Audiovestibular Practices Among Audiologists in the Asia Pacific Region with Established Audiology Professions: A Preliminary Study
(2025-01-01) Wahat N.H.A.; Puraviappan K.P.; Umat C.; Lertsukprasert K.; Wahat N.H.A.; Mahidol University
This preliminary study benchmarks audiovestibular practices among audiologists in Asia-Pacific (APAC) countries with established professional training programs, forming the first phase of a broader initiative covering 17 nations. A structured questionnaire was adapted and updated to include contemporary clinical domains such as vestibular rehabilitation, cochlear implant services, and tele-audiology. The tool underwent expert review and pilot testing, demonstrating strong psychometric properties (Cronbach's α, α = 0.91; KMO = 0.743; Bartlett's p < 0.001). Responses were obtained from 40 audiologists across India, Malaysia, Singapore, Nepal, and New Zealand. Most participants provided services across screening, diagnostic, therapeutic, and rehabilitative domains. Core procedures such as immittance testing, otoacoustic emissions, and auditory brainstem response were widely implemented, while vestibular and rehabilitative services showed increasing integration. Respondents represented diverse professional contexts, including universities, private hospitals, and government healthcare systems. Notably, there was strong professional consensus in support of regional standardization of guidelines, training, and governance mechanisms. These findings validate the adapted tool, establish a foundational dataset, and highlight readiness for regional collaboration. As the broader 17-country study advances, this work provides a baseline for benchmarking, policy development, and capacity building toward harmonized audiovestibular care across the APAC region.
A Bibenzyl from Dendrobium pachyglossum Exhibits Potent Anti-Cancer Activity Against Glioblastoma Multiforme
(2025-10-01) Aung H.M.; Wattanathamsan O.; Sanookpan K.; Hongprasit A.; Muangnoi C.; Phumsuay R.; Rojpitikul T.; Sritularak B.; Bunlue T.; Chantaravisoot N.; Oliva C.R.; Griguer C.E.; Buranasudja V.; Aung H.M.; Mahidol University
Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited treatment options and a poor prognosis. Natural phytochemicals from Dendrobium species, particularly bibenzyl derivatives, possess diverse pharmacological activities, yet their potential against GBM remains largely unexplored. Here, we investigated the anticancer activity of 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (TDB), a potent antioxidant bibenzyl derivative isolated from Dendrobium pachyglossum. In U87MG cells, TDB reduced viability in a dose- and time-dependent manner, suppressed clonogenic growth, induced apoptosis via Bax upregulation and Bcl-xL/Mcl-1 downregulation, and inhibited both mTORC1 and mTORC2 signaling. TDB also impaired cell migration and downregulated epithelial–mesenchymal transition (EMT)-associated proteins. Notably, TDB enhanced the cytotoxicity of temozolomide (TMZ), the current standard of care for GBM. These TMZ-sensitizing properties were further confirmed in patient-derived xenograft (PDX) Jx22 cells. To assess its potential for central nervous system delivery, blood–brain barrier (BBB) permeability was predicted using four independent in silico platforms—ADMETlab 3.0, LogBB_Pred, LightBBB, and BBB Predictor (Tree2C)—all of which consistently classified TDB as BBB-permeable. This predicted CNS accessibility, together with its potent anticancer profile, underscores TDB’s translational promise. Collectively, our findings identify TDB as a plant-derived antioxidant with multifaceted anti-GBM activity and favorable BBB penetration potential, warranting further in vivo validation and preclinical development as a novel therapeutic candidate for GBM.
Two in, one out: A comprehensive phylogeny of the tribe Elsholtzieae (Nepetoideae, Lamiaceae) sheds new light on its generic delimitation
(2025-01-01) Li B.; Xu S.C.; Min D.Z.; Sun Z.P.; Chen Y.P.; Xiao J.F.; Bongcheewin B.; Kim S.; Nuraliev M.S.; Funamoto T.; Sennikov A.N.; Celep F.; Xiang C.L.; Li B.; Mahidol University
Elsholtzieae, the smallest tribe of the subfamily Nepetoideae (Lamiaceae), consists of approximately 70 species within eight genera. The tribe is primarily distributed across East and Southeast Asia, with China, Korea, and Japan representing the center of its diversity. Previous studies have indicated the polyphyly of Keiskea and Elsholtzia; however, due to the limited sampling and the use of only a few DNA markers, the relationships within and between the genera of Elsholtzieae remain unsatisfactorily understood. In this study, we present the most comprehensive phylogenetic analyses of Elsholtzieae to date, utilizing five chloroplast markers (matK, ndhF, rbcL, trnL-F, ycf1) and two nuclear regions (ITS, ETS). Our results confirm the monophyly of Elsholtzieae, which are resolved into five major clades, while at the same time confirming the non-monophyly of Keiskea, Elsholtzia, and possibly Perilla. Consequently, based on the molecular phylogenetic analyses combined with morphological and geographical evidence, we propose an expanded circumscription of the genus Perilla to include Keiskea and Mosla, and reinstate the genus Paulseniella to accommodate three species traditionally included in Elsholtzia. The newly recognized Elsholtzia s.str. is monophyletic with five well-supported lineages, while further work is needed to fully clarify its infrageneric classification. Furthermore, we provide an identification key for all the genera of Elsholtzieae reflecting these taxonomic changes, and checklists of Paulseniella and Perilla.