Mahidol University's Institutional Repository
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Recent Submissions
Structural and Component Alterations in Intertrochanteric Crests of Femur in Induced Short- and Long- Term Diabetes
(2025-12-01) Pianrumluk S.; Lanlua P.; Niyomchan A.; Plaengrit K.; Baimai S.; Sricharoenvej S.; Pianrumluk S.; Mahidol University
Individuals with type I diabetes mellitus have an increased risk of proximal femoral fracture. Moreover, low bone mineral density (BMD), altered serum levels of biomarkers of bone turnover and altered bone morphometry parameters, which affect bone strength, are observed in individuals with diabetes. Thus, this study aimed to compare the components of the intertrochanteric crest of the femur in terms of morphology, bone volume fraction (BV/TV), BMD, trabecular thickness (Tb.Th), and separation (Tb.Sp) by using microcomputed tomography, histomorphology, the determination of cell numbers, and the quantification of empty lacunae and collagen fibres via light microscopy in rats with both short- and long-term streptozotocin-induced diabetes. During both the early and late stages of diabetes, reductions in the femoral BV/TV, BMD, and Tb.Th values and an increase in the Tb.Sp value were observed; moreover, the numbers of osteoblasts and osteocytes decreased, but the numbers of empty lacunae and osteoclasts increased. Additionally, disorganized collagen fibres with lower density were observed in the two diabetes groups. The severity of these changes was more pronounced in the long-term diabetes model, along with thickening of blood vessels and an increased bone marrow adipocyte tissue. All of these changes lead to a decrease in bone quality and fragility, which might be related to an increased risk of femoral fractures in the diabetes groups. Thus, the current understanding of the bone damage that occurs during the development of diabetes might warrant careful consideration of bone strength during the early stages of the disease.
Extracorporeal Life Support for Post-Cardiotomy Acute Right Ventricular Failure: A Retrospective Observational Multicenter Study
(2026-01-01) Bianchi G.; Perazzo A.; Mariani S.; van Bussel B.C.T.; Di Mauro M.; Wiedemann D.; Saeed D.; Pozzi M.; Botta L.; Boeken U.; Samalavicius R.; Bounader K.; Hou X.; Bunge J.J.H.; Buscher H.; Salazar L.; Meyns B.; Mazzeffi M.A.; Matteucci S.; Sponga S.; Ramanathan K.; Russo C.F.; Formica F.; Sakiyalak P.; Fiore A.; Camboni D.; Raffa G.M.; Diaz R.; Wang I.w.; Jung J.S.; Belohlavek J.; Pellegrino V.; Pettinari M.; Barbone A.; Gaiotto F.A.; Garcia J.P.; Shekar K.; Whitman G.; Solinas M.; Lorusso R.; Heuts S.; Schaefer A.K.; Conci L.; Khalil J.; Lehmann S.; Obadia J.F.; Loforte A.; Pacini D.; Kalampokas N.; Jankuviene A.; Flecher E.; Reis Miranda D.D.; Sriranjan K.; Herr D.; Di Eusanio M.; Vendramin I.; MacLaren G.; Sorokin V.; Costetti A.; Marchetto G.; Schmid C.; Castillo R.; Grus T.; Bianchi G.; Mahidol University
Background Post-cardiotomy acute right ventricular failure (aRVF) constitutes a complex clinical challenge that might necessitate escalating interventions, including extracorporeal life support (ECLS). This study evaluated outcomes of adults requiring ECLS for post-cardiotomy aRVF compared with other post-cardiotomy indications. Methods In this multicenter, international, retrospective study, we analyzed patients undergoing post-cardiotomy ECLS from January 2000 to December 2020 and compared patients’ characteristics and in-hospital mortality between aRVF and other indications. Results Of 2010 patients, 240 (12%) had aRVF and 1770 (88%) had other indications for ECLS. Demographics were similar between groups; median age was 65 (55-72) years ( P = .217), and 60% were male ( P = .675). The aRVF group showed higher preoperative right-sided cardiac dysfunction, including preexisting right ventricular failure (aRVF, 22%; other indications, 8%; P < .001) and biventricular failure (aRVF, 12%; other indications, 7%; P = .013). Patients with aRVF more frequently underwent tricuspid valve surgery (aRVF, 20%; other indications, 13%; P = .003) and aortic root procedures (aRVF, 24%; other indications, 13%). They also required longer ECLS support (aRVF, 135 [70-221] hours; other indications, 116 [58-192] hours; P = .025) and longer intensive care unit stay (aRVF, 15 [7-29] days; other indications, 13 [6-25] days; P = .042). Despite more complications, including nonsurgical bleeding (aRVF, 31%; other indications, 25%; P = .042) and persistent right-sided heart failure (aRVF, 50%; other indications, 17%; P < .001), both in-hospital survival (aRVF, 59%; other indications, 61%; P = .526) and long-term survival were comparable (log-rank P = .17). Conclusions Patients requiring ECLS for post-cardiotomy aRVF, despite higher preoperative risks and complex clinical courses, achieve survival rates comparable to those of patients with other indications.
Human Papillomavirus in Neovaginas: Clinical Urgency for Inclusive Screening and Vaccination in Transgender Women
(2026-05-01) Thanchonnang C.; Rattanapitoon S.K.; La N.; Rattanapitoon N.K.; Thanchonnang C.; Mahidol University
Association between occupational exposure, musculoskeletal disorders, occupational depression, and workplace violence in Korean workers: a nationwide large-scale study
(2026-01-01) Acharya S.R.; Bhatta J.; Mailan Arachchige Don R.K.; Acharya S.R.; Mahidol University
Objective: This study investigates the associations between occupational environmental exposure, occupational depression (OD), musculoskeletal disorders (MSD), and workplace violence (WPV) in the general Korean working population. Methods: Utilizing nationally representative samples from the 6th (2020) and 7th (2023) Korean Working Conditions Survey (KWCS), a total of 55,649 eligible workers (weighted) aged 15 years or older were included in the study. Occupational environmental exposures included vibration, noise, temperature extremes, and smoke/fumes/dust; MSD included back pain and upper and lower limb disorders; WPV included physical, sexual, and emotional violence; and OD was assessed using the WHO-5 Well-Being Index. Multivariable-adjusted regression and interaction analyses were performed. Results: Occupational environmental exposures were linked to 11 %–70 % higher odds of MSD. Noise (OR = 1.15), high temperature (OR = 1.13), low temperature (OR = 1.16), smoke/fumes/dust (OR = 1.13), and vibration (OR = 1.03) were linked to elevated odds of OD. Except for vibration, all exposures were positively associated with WPV (OR: noise, 1.35; high temperature, 1.33; low temperature, 1.29; smoke/fumes/dust, 1.31). Significant interaction effects were observed between exposures, gender, and employee type for MSD (P < 0.05), with males and non-regular workers demonstrating greater susceptibility. Workers with OD or WPV exposed to vibration and/or high temperature were at greater risk for MSD. Conclusions: Occupational exposures increase the odds of MSD, and OD and WPV may further amplify these risks. These findings underscore the need for integrated workplace health strategies that address mental health conditions and WPV to improve health outcomes and support workers’ well-being.
Influenza Vaccination Responses in Disabled Stroke Patients: A Single-Center Prospective Observational Study
(2026-01-01) Pakngao A.; Suwatcharangoon S.; Ngamjanyapron P.; Boonnak K.; Suangtamai T.; Rotjanapan P.; Pakngao A.; Mahidol University
Objective: This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods: This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital. Enrolled patients received standard doses of inactivated trivalent influenza vaccine. Seroprotection and seroconversion were assessed using hemagglutination inhibition tests before (T0) and 4–8 weeks (T1) after vaccination. Additional clinical information was gathered, and adverse events were monitored. Results: In total, 161 individuals completed the hemagglutination inhibition analysis. The mean ages (±SD) of the control, functionally independent, and functionally dependent groups were 69.40 (±7.40) years, 71.40 (±8.60) years, and 75.90 (±8.30) years, respectively (p < 0.001). The proportion of participants with hemagglutination inhibition titers greater than 1:40 for the A/Sydney (H1N1) strain was significantly greater in the functionally independent group than in the functionally dependent group (p = 0.031 at T0 and p = 0.003 at T1). The seroconversion rates were significantly higher in the control group than in the functionally independent or functionally dependent group (34.20% vs. 25.40% vs. 19.40%, p = 0.033). The overall incidence rate of probable influenza was 6.2 cases per 100 person-years, and no serious adverse events related to vaccination were reported. Interpretation: The rates of seroprotection were higher for the functionally independent group than for the functionally dependent group. Therefore, the functionally dependent group may require a modified influenza vaccination strategy to achieve more effective immune responses.