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คู่มือปฏิบัติงาน การสำรองข้อมูลเครื่องคอมพิวเตอร์แม่ข่ายของคณะเภสัชศาสตร์ มหาวิทยาลัยมหิดล
(2566) โสรัจ ทัศนเจริญ
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Full-Endoscopic Midline Foraminoplasty: An Alternative Method for Treating Lumbar Foraminal Stenosis
(2024-12-01) Pairuchvej S.; Keorochana G.; Jitpakdee K.; Rittipoldechs C.A.; Kongthavornsakul J.; Pairuchvej S.; Mahidol University
Objective: To describe the full-endoscopic lumbar foraminoplasty with midline skin incision (FEFM) and lateral recess decompression procedure and to report its clinical outcomes at the 1-year follow-up. Methods: Consecutive patients with lumbar foraminal and/or lateral recess stenosis who underwent FEFM procedures were retrospectively reviewed. Clinical outcomes were evaluated with a visual analogue scale (VAS) of back and leg pain and Oswestry Disability Index (ODI) up to 1 year postoperatively. The complications and recurrence rate were also recorded. Results: A total of 30 cases (51 levels) were included (L3–4, 6 cases [11.8%]; L4–5, 23 [45.1%]; L5–S1, 22 cases [43.1%]). VAS scores collected at preoperative, postoperative day 1, 3 months, 6 months, and 1 year were 9.16, 1.7, 1.36, 1.3, and 1.43, respectively. The ODI scores collected at preoperative, postoperative 3 months, 6 months, and 1 year were 46.63, 11.5, 10.66, and 10.46, respectively (p < 0.05). The mean operation time was 88.7 minutes (range, 45–152 minutes). The length of hospital stay was 1.21 days (range, 1–3 days). No immediate complications were identified, and no patients experienced a recurrence of symptoms requiring revision surgery. Conclusion: FEFM is an effective procedure for treating foraminal and/or lateral recess stenosis. It demonstrates the capability to decompress both bilateral foraminal and lateral recess stenosis through a single-entry point.
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Internalization of cell-derived microparticles triggers endothelial pro-inflammatory responses
(2024-12-01) Klaihmon P.; Khuhapinant A.; Kheansaard W.; Pattanapanyasat K.; Klaihmon P.; Mahidol University
BACKGROUND: Increased numbers of circulating microparticles (MPs) have long been documented in thalassemia and are considered as a contributing factor in developing the thromboembolic events (TEEs), which are associated with endothelial dysfunction. Indeed, the cellular and molecular mechanisms by which MPs and endothelial cells interact and their consequences remain poorly investigated. OBJECTIVE: The present study aims to compare the biological effects of MPs obtained from healthy subjects and β-thalassemia/HbE patients on endothelial pro-inflammatory responses. METHODS: MPs isolated from plasma by two-step centrifugation from 10 healthy donors, 19 splenectomized and 30 non-splenectomized β-thalassemia/HbE patients were first characterized for their cellular origins, then counted and incubated with primary human umbilical vein endothelial cells (HUVECs). Internalization of MPs into HUVECs and their induction on endothelial cell activation and pro-inflammatory responses were determined. RESULTS: MPs either from healthy or β-thalassemia/HbE patients could become internalized into endothelial cells, but unlike MPs from healthy donors and non-splenectomized patients, MPs from splenectomized patients were the most active and induced the 2-fold up-regulation of pro-inflammatory genes, IL1B, CXCL8, and CCL2 and 4-fold increase in interleukin-1β. In addition, MPs from both healthy subjects and splenectomized patients at 106/ml failed to trigger the secretion of endothelial IL-6 and IL-8 while higher MP concentration at 5 × 10⁶/ml significantly induced this secretion. CONCLUSIONS: Plasma MPs isolated from splenectomized β-thalassemia/HbE patients are capable of triggering pro-inflammatory responses from endothelial cells reflected at both gene and protein levels.
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Chronic cough management: Practical guidelines and PICO-based evidence for treatment
(2024-12-01) Kanjanawasee D.; Poachanukoon O.; Sriprasart T.; Chirakalwasan N.; Saiphoklang N.; Athipongarporn A.; Senavonge A.; Kamalaporn H.; Sanguanwong N.; Mitthamsiri W.; Chiewchalermsri C.; Suetrong B.; Suwanchanratsamee A.; Tantilipikorn P.; Maneerattanaporn M.; Jaruchinda P.; Kawamatawong T.; Luvira V.; Sombuntham P.; Sompornrattanaphan M.; Suwanwech T.; Chotchai N.; Ruxrungtham K.; Boonsawat W.; Brannan J.D.; Song W.J.; Pornsuriyasak P.; Kanjanawasee D.; Mahidol University
This part reviews the management of chronic cough and proposes a management algorithm. Despite proven improvements in quality of life following chronic cough treatment, a clear understanding of the disease and the evidence for the efficacy of some treatments remain vague. Eight key questions regarding the treatment in the uncertain areas were systematically addressed based on the PICO framework and applying the GRADE system for evidence synthesis to provide the strength of recommendation and quality of evidence for key questions, with narrative components for the description of other chronic cough treatment including non-pharmacological therapy. Practical diagrams were developed to facilitate clinical decision-making on treatment. Our guideline introduces the concept of the cough management process for guiding practitioners to assess chronic cough using a holistic approach.