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Recent Submissions
Factors influencing the intention to use Thai traditional medical postpartum care among pregnant and postpartum women in Bangkok: a cross-sectional study
(2025-12-01) Sirichai L.; Leenatom K.; Jiranorrawat C.; Chaichana C.; Hounnaklang N.; Sirichai L.; Mahidol University
Background: Thai traditional medical postpartum care (TMPC) has been an integral part of traditional practices in Thailand for centuries, offering benefits such as bodily restoration and alleviation of postpartum symptoms. Despite its recognized advantages, the utilization of TMPC has currently declined. This study aimed to investigate the factors influencing the intention to use TMPC among pregnant and postpartum women in Bangkok. Methods: A cross-sectional study utilizing a self-administered questionnaire was conducted between September and December 2023 across four hospitals. The data were analyzed using multivariable logistic regression to identify factors associated with the intention to use TMPC. Results: Among 485 participants, 55.9% expressed an intention to use TMPC (95%CI: 51.3-60.2%). A secondary education or a vocational certificate (AOR = 3.21, CI 1.30–7.95), a bachelor’s degree or higher (AOR = 4.00, CI 1.51–10.58), sufficient income and savings (AOR = 2.11, CI 1.05–4.23), having used TMPC (AOR = 2.88, CI 1.51–5.49), subjective norm scores greater than the 50th percentile (AOR = 1.98, CI 1.17–3.36), and perceived behavioral control scores greater than the 50th percentile (AOR = 4.04, CI 2.44–6.69) were positive factors associated with the intention to use TMPC. Conclusion: The significant factors of intention to use TMPC were education level, financial situation, prior experience with TMPC, subjective norm, and perceived behavioral control. Our findings provide the Thai government with important information that they may use to further their campaigns to encourage usage, such as incorporating services of TMPC, like breast massage and herbal compress, into their usual procedures for postpartum women before discharging hospitals so that they can gain a pleasant experience with Thai traditional medicine. Clinical trial number: Not applicable.
Chlamydia trachomatis infections among men who have sex with men and transgender women attending four community-based clinics in Thailand, 2019–2021
(2025-01-01) Sillabutra J.; Pattanasin S.; Wanichnopparat W.; Hiransuthikul A.; Jareinpituk S.; Suriwong S.; Phanuphak N.; Satitvipawee P.; Sillabutra J.; Mahidol University
Background: Chlamydia trachomatis (CT) infections are prevalent and often asymptomatic. Point-of-Care (PoC) tests offer a diagnostic option. We described the incidence and predictors of CT infection using secondary data collected from men who have sex with men (MSM) and transgender women (TGW) attending Community-Based Organizations (CBOs) clinics in Thailand. Methods: MSM and TGW aged ≥18 and had HIV risks were enrolled and followed for 12 months with visits every 3 months. Behavioral risks and Sexually Transmitted Infection testing were assessed at every visits. Specimens were collected via pharyngeal swab, urine sample, rectal swab, and neovaginal swab for TGW. These specimens were tested for CT using PoC test. The incidence was calculated using survival analysis, and the Cox regression model for multiple failures. Results: From 2019–2021, 1886 participants were enrolled. Of these, 89.7% were MSM; 10.3% were TGW: 20.7% were lost to follow-up. Of the remaining participants, 18.2% had CT at baseline, with 36.4% experiencing repeat infections. The incidence rate of CT was 42.9 infections per 100 person-years. Predictors of CT infections included enrollment year, age 18–24 years, HIV status, pre-exposure prophylaxis and condom use. Conclusion: Repeat CT infections were common. CBOs should incorporate POC STI testing into services, and the provision of STI prevention strategies.
Characterization and Evaluation of Lactobacillus plantarum LC5.2 Isolated from Thai Native Pigs for its Probiotic Potential in Gut Microbiota Modulation and Immune Enhancement
(2025-06-17) Khongkool K.; Taweechotipatr M.; Payungporn S.; Sawaswong V.; Lertworapreecha M.; Khongkool K.; Mahidol University
Probiotic supplementation, particularly with Lactobacillus species, enhances growth performance, maintains gastrointestinal microbial balance, and prevents infections in livestock. This study isolated Lactobacillus strains from the feces of healthy native pigs in southern Thailand and assessed their probiotic properties and safety through both in vitro and in vivo evaluations. Nine Lactobacillus strains showed probiotic potential, with Lactobacillus plantarum LC5.2 demonstrating the best characteristics. This strain tolerated both acid and bile (100% tolerance) and exhibited strong adhesion properties, including high auto-aggregation (69.74%), cell surface hydrophobicity (77.14%), adhesion to Caco-2 cells (9.31%), and biofilm formation. It also exhibited antibacterial activity, inhibiting EHEC, EPEC, and Salmonella Typhimurium through organic acid production. Co-aggregation with these pathogens ranged from 60.83% to 74.09%. Safety evaluations showed no hemolytic activity, susceptibility to antibiotics, and co-existence with other probiotics. In mice, L. plantarum LC5.2 showed no toxicity, with normal food intake, behavior, and weight gain. No abnormalities were found in the small intestine, colon, liver, or spleen. Mice administered the probiotic had significantly higher intestinal IgA levels. Gut microbiome analysis revealed no notable structural alterations but indicated an increase in beneficial bacteria, including Lactobacillus. These results suggest that L. plantarum LC5.2 demonstrates strong probiotic potential, safety, and benefits for gut health, making it a promising candidate for livestock applications.
Faecal short-chain fatty acids and nutritional factors in Thai adults with hypercholesterolaemia compared to normocholesterolemic subjects
(2025-01-01) Thiyajai P.; Trangcasanchai P.; Thapprathum P.; Soonkum T.; Sridonpai P.; Kitdumrongthum S.; Judprasong K.; Kriengsinyos W.; Prachansuwan A.; Thiyajai P.; Mahidol University
Previous studies have highlighted differences in faecal short-chain fatty acids (SCFAs) between hypercholesterolemic (HC) and normocholesterolemic (NC) individuals; however, the impact of nutritional factors on SCFAs remains underexplored. This cross-sectional observational study involved 42 HC and 38 NC Thai adults and examined faecal SCFA concentrations and their associations with nutritional factors. Aliphatic (acetic, propionic, butyric acids) and branched (isobutyric and isovaleric acids) SCFAs were analysed. Although NC participants exhibited higher aliphatic and total SCFAs than HC participants, these differences were insignificant. Carbohydrate intake was positively associated with acetic and propionic acid, in the NC group. Sugar intake was negatively correlated with isobutyric and isovaleric acids in the NC group but positively correlated in the HC group. These findings suggest less efficient sugar and carbohydrate fermentation in the HC group, potentially affecting SCFA profiles. Future studies should investigate gut microbiota composition, bile acid secretion and gut pH as contributing factors.
Prediction model for probability of deceased donor kidney transplantation among transplant candidates in waiting list
(2025-12-01) Sutharattanapong N.; Ingsathit A.; Thotsiri S.; Wiwattanathum P.; Thammanichanond D.; Thakoorabutr P.; Thakkinstian A.; Kantachuvesiri S.; Sutharattanapong N.; Mahidol University
Background: The rapid increase in end-stage kidney disease (ESKD) patients compared to available organ donors remains a significant challenge. This study aimed to externally validate and update the Scientific Registry of Transplant Recipients (SRTR) prediction model for receiving deceased donor kidney transplantation (KT) among Thai patients on the waiting list. Methods: This retrospective study included 3,923 patients registered for deceased donor KT. The original SRTR score was calculated. The primary outcome was the time to deceased donor KT. Cox regression analysis was used to evaluate associations between the SRTR score, additional predictors, and time to KT. The SRTR model was revised by re-estimating individual coefficients and updated by incorporating significant predictors. Discriminative performance was assessed using Harrell’s C-index. Results: The original SRTR model performed poorly in our cohort, with a C-index of 0.521. After revision, the C-index slightly improved to 0.662. The updated model, incorporating nine predictors (sex, blood group, diabetes, peripheral vascular disease, ESKD etiology, dialysis vintage, history of prior kidney transplantation, panel reactive antibody, and anti-HBs antibody status), achieved a C-index of 0.744, indicating good discriminative performance. Conclusion: The updated prediction model demonstrated good predictive performance and may be applied to optimize the management of transplant candidates on the waiting list in the Thai population. Clinical trial number: Not applicable.