Mahidol University's Institutional Repository
คลังสารสนเทศสถาบันของมหาวิทยาลัยมหิดล
"Wisdom Repository You Discover"
To collect Mahidol University's academic publications and intellectual properties more than 39 faculties
To present over 50,000 items of information in digital formats
To make it easy to access to all information at anytime, anywhere
Communities in Mahidol IR
Select a community to browse its collections.
Recent Submissions
Universal newborn hearing screening outcomes based on national health policy in Chiangrai Prachanukroh Hospital, Thailand
(2026-12-01) Parangrit K.; Kulprachakarn K.; Isaradisaikul S.K.; Sillabutra J.; Parangrit K.; Mahidol University
Background: Universal newborn hearing screening (UNHS) is essential for early identification of congenital hearing loss to decrease the adverse effects of a child’s speech and language development. Since 2021, Thailand has enforced newborn hearing screening, followed by the national health policy of the Ministry of Public Health. In order to meet this objective, the quality of these programs should be monitored using internationally recognized benchmarks. This study aimed to analyze the UNHS outcomes according to the national health policy and standard benchmarks. Methods: A retrospective study was conducted at Chiangrai Prachanukroh Hospital, a tertiary care hospital, from December 2021 to November 2022. All newborns delivered in a one-year period who underwent hearing screening were recruited. The coverage rate, rates of diagnostic hearing evaluation, and hearing rehabilitation were analyzed and compared between the well-baby newborns (WBN) and high-risk newborns (HRN). Results: Of 4,216 newborns delivered, 3,363 (79.8%) were WBN, and 853 (20.2%) were HRN. The screening coverage rates before 1 month of age were 94.6% and 72.2%, and referral rates were 34.7% and 34.1% for WBN and HRN, respectively, showing significant differences. The follow-up return rates were 51.9% and 45.7%, audiological diagnosis within 3 months of age were 11.8% and 10.5%, considering diagnosis within 6 months of age were 52.7% and 42.1% for WBN and HRN, respectively, showing without significant differences. Eight children were diagnosed with sensorineural hearing loss, three from the WBN group and five from the HRN group. One child, in the high-risk group, received bilateral hearing aids and speech therapy. Conclusion: UNHS serves as a critical initial measure for the early identification of hearing loss, paving the way for timely interventions. Despite the preliminary indicators not meeting the standard benchmarks, there is a clear necessity for systematically developing implementation protocols to enhance the program’s efficacy. The national health policy in Thailand should persist in its efforts, including providing resources such as manpower, money, and materials (3M’s), to ensure the program’s success.
The impact of colistin minimum inhibitory concentration on clinical failure and mortality: insights from the OVERCOME trial
(2026-01-01) Pogue J.M.; Rybak M.J.; Abdul-Mutakabbir J.C.; Stamper K.; Marchaim D.; Thamlikitkul V.; Carmeli Y.; Chiu C.H.; Daikos G.; Dhar S.; Durante-Mangoni E.; Gikas A.; Kotanidou A.; Paul M.; Roilides E.; Samarkos M.; Sims M.; Tancheva D.; Tsiodras S.; Kett D.H.; Patel G.; Calfee D.P.; Leibovici L.; Power L.; Munoz-Price S.; Susick L.; Latack K.; Chiou C.; Divine G.; Ghazyaran V.; Narayanan N.; Kaye K.S.; Pogue J.M.; Mahidol University
Objectives Colistin is an essential antibiotic against carbapenem-resistant Gram-negative bacilli. Pharmacokinetic and pharmacodynamic limitations impact its efficacy, and susceptibility breakpoints equivocate regarding interpretation of MIC values. This post hoc analysis of the OVERCOME trial investigated the association between colistin MIC and outcomes. Methods OVERCOME, a randomized, double-blind, placebo-controlled trial, compared colistin monotherapy with colistin plus meropenem for treatment of carbapenem-resistant Gram-negative bacilli pneumonia and/or bloodstream infections. Outcomes were compared between participants whose infections were caused by pathogens with colistin MIC values ≤1 mg/L and those with MIC values of 2 mg/L. Results Among 369 included participants, the mean age was 67.7 ± 15.9 years, 246 (67%) were in the intensive care unit, 251 (68%) had pneumonia, and 286 (78%) were infected with Acinetobacter baumannii . Overall, no association between an infecting pathogen with an MIC of 2 mg/L and either clinical failure (adjusted odds ratio [aOR]: 1.59 [95% CI: 0.72–3.52]) or 28-day mortality (aOR: 1.62 [95% CI: 0.85–3.09]) was demonstrated. Among participants receiving monotherapy, an infecting pathogen with an MIC of 2 mg/L was independently associated with both clinical failure (aOR: 3.59 [95% CI: 1.10–11.77]) and 28-day mortality (aOR: 3.22 [95% CI: 1.32–7.84]). Among participants receiving combination therapy, no association was demonstrated between MIC and outcomes. Conclusions When using colistin-based therapy for pathogens with an MIC of 2 mg/L, these findings support colistin and meropenem combination therapy over colistin monotherapy, particularly for pneumonia due to A. baumannii .
NiO Nanoparticle-Modified PTAA Hole Transport Layers for High-Efficiency and Stable Large-Area Perovskite Solar Cells
(2026-06-22) Sukgorn N.; Kaewprajak A.; Lapawae K.; Sinthiptharakoon K.; Treetong A.; Hasuchon C.; Gamonchuang J.; Kayunkid N.; Nakajima H.; Amloy S.; Maiaugree W.; Infahsaeng Y.; Rujisamphan N.; Kanjanaboos P.; Ruankham P.; Wongratanaphisan D.; Promarak V.; Sagawa T.; Kumnorkaew P.; Sukgorn N.; Mahidol University
The hole transport layer (HTL) plays a central role in governing charge extraction, efficiency, and long-term stability in perovskite solar cells (PSCs). Although poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] (PTAA) is widely used as an organic HTL, its limited hole mobility and thermal robustness restrict device durability and scalability. Here, we report a hybrid organic−inorganic HTL formed by incorporating NiO nanoparticles into PTAA to simultaneously improve charge transport and thermal stability. Comprehensive spectroscopic and electrical analyses reveal that NiO incorporation deepens the valence band position, enhances hole mobility, accelerates interfacial hole extraction, and suppresses carrier recombination in PTAA:NiO films. As a result, planar n−i−p PSCs employing PTAA:NiO (10 mg mL−1) achieve a champion power conversion efficiency (PCE) of 20.76%, outperforming pristine PTAA-based devices (19.50%) while retaining 86.5% of their initial efficiency after 6000 h under ISOS-D-1 storage conditions. Importantly, NiO incorporation also improves module-level robustness by mitigating thermally induced interfacial degradation during high-temperature encapsulation. Scalable 10 × 10 cm2 minimodules deliver a PCE of up to 14.18% and retain 85.1% of their initial performance after 5000 h. Furthermore, integrated minimodules successfully powered a standalone PM2.5 monitoring system under indoor illumination, highlighting the practical potential of hybrid-HTL PSCs for durable large-area photovoltaic and low-power Internet-of-Things applications.
Genomic insights into Salmonella Rissen from Thailand: Prophage substitution in phase 2 flagellar-encoding region and hotspot of multidrug resistance genes in the chromosome
(2026-10-02) Phaophu P.; Orsi R.H.; Wirth S.E.; Gray A.S.; Wiedmann M.; Chaturongakul S.; Phaophu P.; Mahidol University
Salmonella Rissen (6,7, 14 :f,g:-) has recently emerged in Thailand; a high prevalence of multidrug resistance (MDR) has been reported. S . Rissen is a monophasic serotype, lacking phase 1 or phase 2 flagellin, and its biphasic ancestor remains unknown. In this study, pangenome SNP analysis was performed on 119 Salmonella serotypes (i.e., 325 genomes) that share antigens with S . Rissen, including those with the 6,7, 14 O antigen, f,g phase 1 flagellin antigen, or the absence of phase 2 antigen, as well as those in closely related clades. Although the biphasic ancestor of S . Rissen was not determined, all 109 Thai S. Rissen isolates belong to S . Rissen lineage A, which shares a most recent common ancestor (MRCA) with another monophasic serotype, S . Oranienburg lineage G; the antigenic formula (6,7, 14 :m,t:[z57]; [z57]), however, indicates that some rare S . Oranienburg isolates are biphasic. Thai S . Rissen isolates not only lack the phase 2 flagellin gene, fljB , but the entire fljAB-hin region is replaced by a SEN8-like prophage. However, unlike MDR Salmonella Typhimurium monophasic variant, 4,[5],12:i:- in which AMR genes replace the fljAB-hin region, AMR genes in S . Rissen were detected within the tnsD - silE region in the chromosome, suggesting an alternative AMR hotspot in S . Rissen. This tnsD - silE region was reported as a part of the Tn 6777 transposon that can translocate from the S . Rissen chromosome to a plasmid, suggesting mobility of AMR genes in S . Rissen genomes. This study highlights the single emergence and clonal expansion of Thai MDR S . Rissen isolates and the plasticity of S . Rissen genomes.
Improving Knowledge, Dietary Behavior, and Clinical Outcomes Through a Protein and Energy Intake Self-Care Support Program among Monks Undergoing Hemodialysis: A Quasi-Experimental Study
(2026-07-01) Thakhat S.; Phinitkhajorndech N.; Chaiviboontham S.; Thakhat S.; Mahidol University
The Buddhist monastic discipline includes regulations regarding monks’ consumption of food and drinks. Even in cases of health problems and with exceptions allowed, most monks still adhere to the practice of eating one to two meals per day. This limits their ability to obtain sufficient nutrients, increasing the risk of malnutrition. Malnutrition and protein-energy wasting commonly occur in people undergoing hemodialysis and may be of intense concern for Buddhist monks. This quasi-experimental study, a one-group pre-posttest with repeated measures, aimed to examine the effects of the Protein and Energy Intake Self-Care Support Program on knowledge, self-care behaviors, and clinical outcomes among 30 monks undergoing hemodialysis at the Priest Hospital in Bangkok, Thailand. The participants received an intervention for twelve weeks. The instruments used were a Personal and Health Information Form, the Knowledge of Protein and Energy Intake Questionnaire, and a 24-Hour Dietary Recall Record Form to evaluate dietary behaviors as self-care behaviors. Descriptive statistics and one-way repeated-measures ANOVA were used to analyze data. The program led to a significant increase in mean scores for knowledge, dietary behaviors, and clinical outcomes (serum albumin and protein catabolic rate). Repeated measures analysis showed that knowledge significantly improved across three evaluation time points. Dietary behaviors and clinical outcomes significantly improved across all four evaluation time points. These findings suggest that the intervention effectively promotes long-term enhancements in both nutritional status and clinical outcomes in monks undergoing hemodialysis. Nurses can apply this intervention in nursing practice. However, further testing of this intervention is needed through a randomized controlled trial in a multi-site study.