Mahidol University's Institutional Repository
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Correction: High-throughput screening of FDA-approved drugs identifies colchicine as a potential therapeutic agent for atypical teratoid/rhabdoid tumors (AT/RTs)
(2025-01-01) Kanjanasirirat P.; Jearawuttanakul K.; Seemakhan S.; Borwornpinyo S.; Wongtrakoongate P.; Hongeng S.; Charoensutthivarakul S.; Kanjanasirirat P.; Mahidol University
Correction: High-throughput screening of FDAapproved drugs identifies colchicine as a potential therapeutic agent for atypical teratoid/rhabdoid tumors (AT/RTs) Phongthon Kanjanasirirat,abc Kedchin Jearawuttanakul,c Sawinee Seemakhan,c Suparerk Borwornpinyo,cd Patompon Wongtrakoongate,ef Suradej Hongengcg and Sitthivut Charoensutthivarakul*acf Correction for ‘High-throughput screening of FDA-approved drugs identifies colchicine as a potential therapeutic agent for atypical teratoid/rhabdoid tumors (AT/RTs)’ by Phongthon Kanjanasirirat et al., RSC Adv., 2025, 15, 12331–12341, https://doi.org/10.1039/D5RA01341K. The authors regret the omission of Tanawadee Khumpanied from the Acknowledgements. The correct Acknowledgements are as shown here. This research was partially supported by the Ramathibodi Foundation and Thailand Center of Excellence for Life Sciences (TCELS), and also by the Faculty of Science, Mahidol University via the Reinventing University Project. The authors would like to thank Dr Witchuda Saengsawang, Dr Jiraporn Panmanee and Dr Sujira Mukda for discussions and Ms Tanawadee Khumpanied for preliminary data collection. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
Damnacanthal Suppresses Breast Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest via NF-ĸB Signaling
(2026-04-01) Jongcharoen O.; Reabroi S.; Sanvarinda P.; Tungmunnithum D.; Parichatikanond W.; Pinthong D.; Jongcharoen O.; Mahidol University
Breast cancer is the most common cancer diagnosed and the leading cause of death for women worldwide. Noni (Morinda citrifolia L.) contains an anthraquinone called damnacanthal (3-hydroxy-1-methoxy-anthraquinone-2-aldehyde), which is known to inhibit the growth of many types of cancer cells. The purpose of this study is to examine the anticancer effects of damnacanthal on cell proliferation, apoptosis, and cell cycle in breast cancer cells and its underlying signaling pathway, including nuclear factor kappa B (NF-ĸB), epidermal growth factor receptors (EGFR), and PI3K/AKT/PTEN. Damnacanthal reduced cell viability in both normal and triple-negative breast cancer cell lines, MCF-7 and MDA-MB-231, respectively. In MCF-7 cells, damnacanthal induced late apoptosis and increased cell cycle arrest in the G0/G1 and S phase, decreased RELA gene expression, and enhanced TNF-α gene expression. However, it had no effect on the protein expression of PI3K/AKT. Damnacanthal exerted anticancer activity on MCF-7 cell lines via blocking NF-ĸB (subunit p65) expression at mRNA levels in the PI3K/AKT-independent manner. These findings highlight the potential benefits of damnacanthal as a promising NF-ĸB inhibitor for cancer prevention or treatment against breast carcinoma.
Multifunctional DIPAI Surface Passivation: Enhancing Efficiency and Stability of Perovskite Solar Cells Across Lighting Conditions
(2025-08-11) Usulor C.E.; Passatorntaschakorn W.; Khampa W.; Musikpan W.; Tipparak P.; Singh S.; Ogbuagu I.C.; Seriwattanachai C.; Nakajima H.; Ngamjarurojana A.; Gardchareon A.; Kanjanaboos P.; Ruankham P.; Wongratanaphisan D.; Usulor C.E.; Mahidol University
Defect-mediated recombination remains a critical bottleneck for perovskite solar cells (PSCs), limiting both the efficiency and operational stability. Passivating these defects to suppress recombination is a crucial strategy for improving the performance of PSCs. Here, di-isopropylammonium iodide (DIPAI) was introduced as a multifunctional surface ligand that not only passivated defects and stabilized the perovskite phase but also fine-tuned energy-level alignment, facilitating efficient carrier transfer between the perovskite layer and the charge transport layers. The amino groups in DIPAI coordinate with uncoordinated Pb2+ ions and organic cations, promoting secondary grain growth and suppressing nonradiative. As a result, DIPAI-treated PSCs show a significant PCE enhancement of 8.3%, from 13.35 to 14.46% under one-sun illumination, and a notable improvement in indoor performance from 28.25 to 29.65% under 1000 lx LED lighting, placing them among the top-performance mixed halide perovskite devices reported. Furthermore, the devices demonstrate excellent stability, maintaining 94% of their initial efficiency after 1000 h under humid conditions (30–35%RH). This work introduces a robust and scalable surface engineering strategy for defect suppression and stability enhancement, advancing the practical deployment of PSCs in both indoor and outdoor lighting environments.
Occurrence of microplastics in fishing cat (Prionailurus viverrinus) scat: Hidden threats to wetland ecosystems of Thailand
(2026-06-15) Wongson T.; Tanpradit N.; Arya N.; Khaewphakdee S.; Pattanarangsan R.; Panyacharoen B.; Sukmasuang R.; Serieys L.E.K.; Wong W.M.; Income N.; Wongson T.; Mahidol University
Wetland ecosystems in Southeast Asia face threats from habitat degradation and plastic pollution, with microplastics posing emerging risks to biodiversity and apex predators like the Vulnerable fishing cat (Prionailurus viverrinus). This study investigated microplastic occurrence in fishing cat scat from the Khao Sam Roi Yot (KSRY) wetland in Thailand, a key habitat supporting an estimated 127 individuals, to assess contamination prevalence, characteristics, and sources. From August 2022 to July 2023, 192 scat samples were collected across aquaculture, agricultural, and coastal plain habitats and processed using hydrogen peroxide digestion, followed by stereomicroscopic examination for visual identification and Fourier-transform infrared (FTIR) spectroscopy examination for polymer identification. Anthropogenic particles were detected in 28 scat samples (14.6%), with confirmed plastics in 26 scat samples (13.5%), yielding 251 plastic particles primarily as fragments (86.1%), blue in color (75.3%), and polypropylene (PP) (87.6%). Contamination was highest in aquaculture areas (67.9% of positive scat samples), corroborated by environmental surveys identifying plastic debris from nets, sacks, and bottles. These findings provide the first evidence of microplastic ingestion in fishing cats in Thailand possibly via trophic transfer from contaminated prey, highlighting potential health risks including gastrointestinal damage and chemical exposure. Urgent mitigation through waste management in aquaculture and policy interventions is essential to safeguard wetland ecosystems and endangered species conservation.
Impact of combined unilateral mastectomy and ovariohysterectomy on acute phase response and wound healing in dogs with mammary gland tumors
(2026-12-01) Wongbandue G.; Prompiram P.; Chandrasakha P.; Prapaiwan N.; Wongbandue G.; Mahidol University
Background: Canine mammary gland tumors (CMTs) are among the most common neoplasms in female dogs, and surgical excision is the standard modality for treatment of CMTs. Unilateral mastectomy (UM) is frequently combined with ovariohysterectomy (OVH), which may lead to different levels of systemic inflammation and wound-healing. This study aimed to evaluate pain intensity, serum acute phase proteins (APPs), proinflammatory cytokines, and wound healing in dogs submitted to OVH (control), UM, or UM concomitant with OVH (BT). Twenty-nine female dogs were prospectively enrolled and divided into three groups: control (n = 8), UM (n = 10), and BT (n = 11). Pain was measured using the Glasgow Composite Pain Scale. Serum C-reactive protein (CRP), amyloid A (SAA), haptoglobin, interleukin (IL)-1β, and IL-6 levels were determined at five time points, including pre-surgery, after emergence from anesthesia, and on postoperative days 1, 3, and 7, using enzyme-linked immunosorbent and fluorescent immunoassays. Results: Pain scores peaked after emergence from anesthesia in both the UM and BT groups compared to controls (P < 0.05), with non-significant differences between UM and BT groups. In the UM and BT groups, serum CRP and SAA levels rose significantly following surgery, peaking on day 1 and gradually dropping subsequently. On day 1, both the UM and BT groups exhibited significantly higher CRP and SAA levels than the control group (P < 0.05), whereas the difference between the UM and BT groups was non-significant. Wound healing was slower in the BT group, which had a significantly higher wound score on day 3 than the control group (P < 0.05). Conclusions: UM, performed alone or in combination with OVH, was associated with transient increases in postoperative pain, APP responses, and wound scores compared with OVH alone, particularly during the early postoperative period. SAA and CRP were the most consistent and sensitive biomarkers for detecting postoperative inflammation under the present sampling schedule, whereas IL-1β and IL-6 showed limited discriminatory capacity, likely due to their rapid and transient kinetics. Therefore, monitoring blood CRP and SAA levels provides supportive information for assessing postoperative inflammatory responses in dogs undergoing mammary tumor surgery.