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Recent Submissions
Pharmacoepidemiologic Trends and Factors Associated With Use and Dosing of Newer Antidepressants in 8357 Patients Across Asia: A Two-Decade Perspective
(2026-03-01) Ying J.; Chew Q.H.; Si T.M.; Kallivayalil R.A.; Tanra A.J.; Nadoushan A.H.J.; Chee K.Y.; Javed A.; Pariwatcharakul P.; Park S.C.; Lin S.K.; Huang K.L.; Inada T.; Grover S.; Xiang Y.T.; Sartorius N.; Shinfuku N.; Kato T.A.; Baldessarini R.J.; Sim K.; Ying J.; Mahidol University
Introduction: Previous studies of antidepressant prescribing patterns largely were limited to a single location or time, and very few involved Asia. This Asian Psychotropic Prescription Patterns Consortium study investigated pharmacoepidemiologic trends and factors associated with use and dosing of newer antidepressants across 12 Asian sites in 2003, 2013, and 2023. Methods: Data from each site included demographic, treatment setting, clinical features, and type and dosage of antidepressants prescribed. Sociodemographic and clinical variables were examined using univariate methods, followed by multivariable logistic and linear modeling. Results: Of 8357 adult participants (59.8% female), 82.8% received at least one modern antidepressant. Use of these drugs was strongly associated with more recent year, younger age, inpatient status, and affective or anxiety-related disorders. Higher daily antidepressant doses were associated with inpatient status, male gender, more recent year, and younger age. Discussion: This large, multisite study provides a two-decade overview of evolving antidepressant-prescribing patterns in 12 Asian sites and highlights patient characteristics associated with prescription of newer antidepressants and their dosage. Needed are further studies of psychotropic prescribing practices related to specific illness subtypes and their impact on psychosocial functioning over time among Asian patients.
Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study
(2026-01-01) Kulthanan K.; Bernstein J.A.; Rudenko M.; Salameh P.; Komoltri C.; Hameed Z.A.; Adışen E.; Al Abri S.; Al-Ahmad M.; Al Hinai B.; Allenova A.; Alshareef S.; Angkoolpakdeekul N.; Arnaout R.; Bartosińska J.; Cherrez-Ojeda I.; Chularojanamontri L.; Criado P.R.; Elsaeed H.; Criado R.F.J.; Farahat A.; Calle C.A.G.; Giménez-Arnau A.M.; Godse K.; Gotua M.; Gülengül M.; Hide M.; Inomata N.; Jung C.G.; Kasperska-Zając A.; Khoshkhui M.; Kolkhir P.; Krasowska D.; Laomoleethorn J.; Maiorowa A.; Manuskiatti P.; Meshkova R.; Mijakoski D.; Muñoz M.; Nasr I.; de Aquino Arnoldi D.N.S.; Kara R.Ö.; Paringkarn T.; Pérez-Manich J.; Podder I.; Robles-Velasco K.; Rosmaninho I.; Saengthong-aram P.; Shengelidze G.; Sittiwanaruk S.; Tafrishi R.; Mitrevska N.T.; Trajkova V.; Tuchinda P.; Viriyaskultorn N.; Wannawittayapa T.; Wattanasillawat P.; Wilson A.; Ye Y.M.; Zalewska-Janowska A.; Maurer M.; Zuberbier T.; Kulthanan K.; Mahidol University
Background and Objective: Symptomatic dermographism (SD), the most common chronic inducible urticaria subtype, manifests as strip-shaped, pruritic wheals after skin friction. Conclusive data on its associated factors are limited, and direct comparisons between individuals with and without SD remain scarce. We aimed to identify factors associated with SD internationally. Methods: The PREVALENCE-D (Prevalence Estimation of Dermographism) study was an international cross-sectional survey conducted from 2021 to 2024 across 19 countries. An expert-designed questionnaire diagnosed SD and assessed potential associated factors. SD participants were defined as those who self-reported chronic recurrent urticarial dermographism with itch. Factors associated with SD were identified by comparing participants with and without SD. Results: Of 68,513 participants, 3101 had SD (female 73.3%). Their mean age was 40.2 ± 16.2 years. Key factors associated with SD included atopic dermatitis (adjusted odds ratio [aOR] 4.20, 95% confidence interval [CI] 3.62‒4.88) and allergic rhinitis (aOR 2.11, 95% CI 1.88‒2.37). Participants with at least one atopic condition (allergic rhinitis, atopic dermatitis, or asthma) were significantly more likely to have SD (aOR 2.70, 95% CI 2.47‒2.95). Those with all three atopic conditions had a further increased likelihood of SD (aOR 7.75, 95% CI 5.31‒11.29). Other associations included working and older age groups, female sex, dyslipidemia, and thyroid disease. Conclusions: Atopic dermatitis and allergic rhinitis emerged as the strongest correlates of SD, especially those with all three atopic conditions. Thus, allergic comorbidities should be assessed in SD patients. Further research is needed to clarify the pathophysiological relationship between these conditions and SD. [
Discovery of a secreted Bacteroides fragilis mucinase that cleaves mucins with bis-T O-glycans through a carbohydrate binding module-dependent mechanism
(2026-01-01) Narimatsu Y.; Pleguezuelos-Manzano C.; Hornikx D.; Goerdeler F.; Jaroentomeechai T.; Flores K.; Narimatsu S.; Boot C.; Hansen L.; Durbesson F.; Vincentelli R.; Comstock L.; Clevers H.; Taleb V.; Corzana F.; Henrissat B.; Clausen H.; Hurtado-Guerrero R.; Büll C.; Narimatsu Y.; Mahidol University
Degradation of mucins at the host–microbial mucus interphase involves glycosidases that release monosaccharides from O-glycans and mucinases that cleave the mucin protein backbone. Mucinases recognize and cleave peptide bonds at specific sequence motifs with varying O-glycan structures required and/or permissible. Mucinases that digest mucins with intact O-glycans can potentially destroy the protective mucus, while mucinases that only digest mucins with partially degraded O-glycans may serve at a later stage of nutrient sourcing from mucins. Here, we discovered nine CBM-bearing M60-like mucinases across gut commensals and opportunists, including a conserved Bacteroides fragilis mucinase denoted HC11. We also investigated the previously described Bacteroides thetaiotaomicron mucinase BT4244, which together delineates two functional classes with distinct preferences: BT4244 for bis-Tn (GalNAcα1-O-Ser/Thr) and HC11 for bis-T (Galβ1-3GalNAcα1-O-Ser/Thr) O-glycans. Both mucinases harbor carbohydrate-binding modules (CBM32) that bind their cognate O-glycan motifs and are required–together with the catalytic domains–for efficient cleavage of extended mucin domains, which is consistent with cooperative engagement, but are not required for the cleavage of short glycopeptides. We show B. fragilis strains secrete HC11 and degrade mucins only after the removal of sialic acids. Together, these findings expand the mucinase repertoire by nine enzymes spanning commensals and opportunists, demonstrate that CBM32 domains are essential for efficient cleavage of extended mucin substrates likely by promoting multivalent engagement and substrate positioning, and nominateidentify CBM–catalytic cooperation as a mechanism and intervention point for controlling mucus turnover and barrier integrity.
Chronic Malaria Is Associated With Trauma-related Splenic Rupture Requiring Splenectomy
(2026-03-15) Shanti P.A.I.; Alexander K.; Candrawati F.; Andries B.; Kambuaya N.N.; Rini H.; Amelia A.R.; Puspitasari A.M.; Amalia R.; Rahmayenti D.A.; Leonardo L.; Prayoga P.; Trianty L.; Pava Z.; Kenangalem E.; Auburn S.; Price R.N.; Laksanawati I.S.; Buffet P.A.; Noviyanti R.; Anstey N.M.; Poespoprodjo J.R.; Kho S.; Shanti P.A.I.; Mahidol University
Splenic rupture is a recognized complication of acute Plasmodium falciparum and Plasmodium vivax malaria, but the risk of splenic rupture in chronic asymptomatic infections is unknown. In Timika, Papua, Indonesia, we determined the proportion of PCR-detectable asymptomatic peripheral parasitemia in patients undergoing trauma-related splenectomy (2015–21) and found it was more than twice the proportion compared to a 2013 household survey of the general population (87.9% [29/33] vs 38.6% [697/1807]; P <.0001). Our findings suggest asymptomatic parasitemia with either P. falciparum or P. vivax is associated with splenic rupture following trauma, pointing toward an additional consequence of chronic infection in malaria-endemic areas.
Scrub and murine typhus seroprevalence among blood donors in Laos
(2026-03-01) Phuklia W.; Wongsantichon J.; Souksakhone C.; Tanganuchitcharnchai A.; Mukaka M.; Padith K.; Phommasone K.; Mayxay M.; Blacksell S.D.; Dubot-Pérès A.; Robinson M.T.; Ashley E.A.; Phuklia W.; Mahidol University
BACKGROUND: Scrub typhus and murine typhus, caused by Orientia tsutsugamushi and Rickettsia typhi, respectively, are important causes of febrile illness in Laos. Although several studies have assessed rickettsial infection in selected provinces, the nationwide distribution remains unclear. This study aimed to estimate exposure to scrub typhus group (STG) and typhus group (TG) across twelve provinces of Laos and identify potential hotspots. METHODOLOGY: We screened 1,200 serum samples from blood donors (100 per province) for STG and TG IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Samples with optical density ≥ 0.5 were confirmed by immunofluorescence assays (IFA). RESULTS: Overall seroprevalence was 7.26% (95%CI:5.93-8.87) for STG and 4.09% (95% CI:3.11-5.37) for TG. STG seroprevalence was highest in Huaphan (27%), Oudomxay (19%) and Xiangkhuang (17%), all in northern Laos. TG seroprevalence was 10% in both Oudomxay (north) and Attapue (south). Compared with Vientiane Capital, these provinces had significantly higher seropositivity. No significant association was observed with age group. STG seropositivity was higher in males, whereas TG seropositivity was higher in females. CONCLUSION: Rickettsial infections are widespread in Laos, with STG seroprevalence concentrated in the north and TG seroprevalence present in both the north and south, guiding future research priorities and informing targeted public health interventions.