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Recent Submissions
L2 listening boredom and enjoyment dynamics in EFL learning: Experimental insights via experience sampling method and dynamic structural equation modeling
(2026-09-01) Solhi M.; Elahi Shirvan M.; Thumvichit A.; Taherian T.; Solhi M.; Mahidol University
Although emotions in second or foreign language (L2) learning have received increasing attention, dynamic affective experiences associated with specific language skills such as L2 listening remain underexplored. Grounded in Pekrun's (2006) control-value theory (CVT) of achievement emotions, the present experimental study examined the effects of control-supportive and value-enhancing listening instruction on English as a Foreign Language (EFL) learners' listening boredom and enjoyment experiences. Forty-eight learners participated and were assigned to an experimental group (n = 23) and a control group (n = 25). Over eight 45-min sessions conducted across one month, learners in the experimental group engaged in listening tasks designed to enhance perceived control and task value, whereas the control group received teacher-directed and non-intervention listening instruction. An experience sampling method (ESM) design was employed to capture momentary fluctuations in L2 listening boredom and enjoyment. The resulting time-series data were analyzed using dynamic structural equation modeling (DSEM) to disentangle within-person emotional fluctuations from between-person differences over time. Overall, thelearners in the experimental group demonstrated significantly more adaptive emotional trajectories, characterized by reduced boredom and enhanced enjoyment across sessions, compared to their control-group counterparts. These results underscore the importance of perceived control and task value in shaping skill-specific emotional experiences and highlight the pedagogical potential of CVT-informed instructional design for fostering positive emotions in L2 listening classrooms.
Interfacial hydrogen bonding and phase-inversion kinetics drive 3D pore networks in PLA–CNF membranes for dialysis-grade selectivity
(2026-09-01) Khan M.J.; Rashid R.; Karim Z.; Pongchaikul P.; Sawatdee S.; Deeleepojananan C.; Botalo A.; Posoknistakul P.; Srifa A.; Samwang T.; Pakawanit P.; Supruangnet R.; Laosiripojana N.; Wu K.C.W.; Sakdaronnarong C.; Khan M.J.; Mahidol University
Bio-based dialysis membranes could reduce polymer waste and additive leaching risks associated with conventional petroleum-derived dialyzers, but most bio-based systems have not been validated for dialysis permselectivity ( i.e., high passage of uremic toxins with protein retention) nor linked mechanistically to structure formation. Here, we report fully biobased poly(lactic acid)–cellulose nanofiber (PLA–CNF) composite membranes fabricated via scalable casting–phase inversion. CNF loading increased porosity from 58.5% to 75.7% and decreased water contact angle from 116° to 65°, enabling a ∼ 3 × higher water flux from 53.4 to 166.4 L m−2h−1 at 0.5 ± 0.025 bar. In dialysis-mimicking separations, the membranes exhibited remarkably high solute passage, i.e., urea clearance ˃94% and creatinine clearance ˃ 85, with albumin rejection up to 78%. In addition, both pristine and composite membranes were cytocompatible (>85% viability for L929 and Vero cells). These results position PLA–CNF membranes as a sustainable platform for dialyzers and liquid purification modules, with future optimization targeting antifouling/charge-selective interfaces and long-term hemocompatibility under realistic flow regimes.
Anti-carcinoembryonic antigen conjugated resveratrol/sunitinib-loaded polymeric nanoparticles for therapeutic enhancement in colorectal cancer
(2026-10-01) Nonsuwan P.; Insawang K.; Niwetbowornchai N.; Taya S.; Srisawat C.; Dana P.; Saengkrit N.; Nguyen T.; Punnakitikashem P.; Nonsuwan P.; Mahidol University
Colorectal cancer treatment remains limited by poor tumor selectivity, systemic toxicity, and insufficient delivery of combination therapies to three-dimensional tumor-like structures. This study investigates the development and application of anti-carcinoembryonic antigen (anti-CEA) conjugated polymeric nanoparticles co-loaded with sunitinib (SUN) and resveratrol (RSV) for the treatment of colorectal cancer. The nanoparticles, formulated using poly(lactic-co-glycolic acid) (PLGA), exhibited favorable physicochemical properties, including a particle size of 207.6 ± 19.0 nm and a negative surface charge of −24.8 ± 0.7 mV. The nanoparticles exhibited controlled and sustained drug release, enabling the prolonged therapeutic efficacy of SUN and RSV. Functionalization with anti-CEA antibodies enabled selective targeting of colorectal cancer cells, as demonstrated by enhanced internalization in HCT-116 cells with high CEA expression. Consistent with this targeting effect, the anti-CEA-conjugated nanoparticles achieved a 29% relative reduction in cell viability against HCT-116 cells compared to non-targeted counterparts in two-dimensional cultures. Furthermore, the SUN and RSV combination exhibited potent synergistic effects across three-dimensional spheroid models. The anti-CEA functionalized system proved more effective, reducing spheroid volume and cell viability by 10% and 14%, respectively, compared to the non-targeted nanoparticles. These findings highlight the potential of CEA-targeted polymeric nanoparticles for co-delivery of synergistic anticancer agents, offering a promising strategy for colorectal cancer therapy.
Evidence- and opinion-based consensus from Delphi round 1 of the Asian aplastic anemia recommendation development
(2026-01-01) Jang J.H.; Kwong Y.L.; Issaragrisil S.; Hosokawa K.; Yao M.; Chen Y.C.; Mun Y.C.; Zhang F.K.; Wong L.; Nakao S.; Jang J.H.; Mahidol University
Background: Implementing international guidelines for aplastic anemia (AA) in Asia remains challenging due to limited access to advanced diagnostic tools, restricted treatment options, and variation in healthcare policies. This highlights a need for region-specific guidance on the diagnosis and management of AA in Asia. Methods: The Asian Aplastic Anemia Working Group consisted of 10 experts from across Asia (South Korea, Japan, China, Hong Kong, Malaysia, Taiwan, and Thailand) who met virtually twice and developed 16 thematic statements on the diagnosis and management of AA. Using an e-Delphi method, members voted asynchronously on these statements using a 5-point Likert scale. Consensus was predefined as “≥ 80% level of agreement among the Delphi participants.” Results: Sixteen thematic statements and 54 sub-statements were developed. The first three statements addressed AA definition, presentation, and causes; the next four focused on diagnosis and prognosis; and the remaining nine covered management, including clonal evolution, supportive care, and special populations. Fifteen statements reached consensus after the first voting round. However, one statement on the management of severe AA did not achieve consensus in the first round. Conclusion: This e-Delphi method has, for the first time, generated Asian, expert-derived, consensus recommendations for the diagnosis and management of AA.
Factors Associated with Malnutrition in Thai Patients with Heart Failure: A Cross-Sectional Study
(2026-01-01) Huayhongtong R.; Poungkaew A.; Sriyuktasuth A.; Huayhongtong R.; Mahidol University
Background: Malnutrition is a well-established independent predictor of adverse clinical outcomes and reduced quality of life among patients with heart failure (HF). In middle-income countries such as Thailand, nutritional assessment and management in outpatient HF care remain underprioritized. Objective: To examine the association and predictive contribution of fatigue, constipation, comorbidities, and family support to malnutrition among Thai patients with HF. Methods: A cross-sectional predictive study was conducted among 138 patients with HF attending a tertiary hospital in Thailand. Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF). Fatigue, constipation, comorbidities, and family support were measured using the Piper Fatigue Scale-12, Rome IV criteria, Charlson Comorbidity Index, and Family APGAR, respectively. Binary logistic regression analysis was performed to identify independent predictors of malnutrition. Results: Participants had a mean age of 64.77 ± 15.15 years, and 63.0% were male. Overall, 39.9% of participants were malnourished or at risk of malnutrition (28.3% at risk; 11.6% malnourished). All participants reported some degree of fatigue, with 42.7% experiencing moderate-to-severe levels, and 31.2% meeting criteria for constipation. In multivariable analysis, moderate-to-severe fatigue (OR = 5.45, 95% CI 2.33–12.72, p <0.001) and constipation (OR = 4.91, 95% CI 1.88–12.83, p =0.001) were significant independent predictors of malnutrition, collectively explaining 40.5% of the variance (Nagelkerke R2 =0.405). Conclusion: Fatigue and constipation are significant predictors of malnutrition among Thai patients with HF. These findings highlight the importance of routine symptom assessment and early intervention to prevent nutritional deterioration in outpatient HF care.