Publication: Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri
| dc.contributor.author | Sujittra Deesamer | en_US |
| dc.contributor.author | Udom Kokpol | en_US |
| dc.contributor.author | Warinthorn Chavasiri | en_US |
| dc.contributor.author | Soazig Douillard | en_US |
| dc.contributor.author | Vincent Peyrot | en_US |
| dc.contributor.author | Nicolas Vidal | en_US |
| dc.contributor.author | Sebastien Combes | en_US |
| dc.contributor.author | Jean Pierre Finet | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Aix Marseille Universite | en_US |
| dc.date.accessioned | 2018-08-24T01:39:11Z | |
| dc.date.available | 2018-08-24T01:39:11Z | |
| dc.date.issued | 2007-12-24 | en_US |
| dc.description.abstract | Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 with an IC50value amounting to 5.7 μM. All the drugs modestly inhibit the in vitro microtubule assembly, independently of the cytotoxic ability. Natural compounds 1 and 2 have no antibacterial activity, but are potent inhibitors of the Fusarium oxysporum phytopathogenic fungal growth. © 2007 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Tetrahedron. Vol.63, No.52 (2007), 12986-12993 | en_US |
| dc.identifier.doi | 10.1016/j.tet.2007.10.030 | en_US |
| dc.identifier.issn | 00404020 | en_US |
| dc.identifier.other | 2-s2.0-36148973932 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/24057 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36148973932&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36148973932&origin=inward | en_US |