Publication: Surface-functionalized Electrospun Polycaprolactone Fiber for Culturing Stem Cell from Human Exfoliated Deciduous Teeth Culture
Issued Date
2020-10-01
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ISSN
18750052
12299197
12299197
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2-s2.0-85094682463
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Mahidol University
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SCOPUS
Bibliographic Citation
Fibers and Polymers. Vol.21, No.10 (2020), 2215-2223
Suggested Citation
Jirasak Jitpibull, Thammasit Vongsetskul, Hathaitip Sritanaudomchai, Nathaphon Tangjit Surface-functionalized Electrospun Polycaprolactone Fiber for Culturing Stem Cell from Human Exfoliated Deciduous Teeth Culture. Fibers and Polymers. Vol.21, No.10 (2020), 2215-2223. doi:10.1007/s12221-020-1147-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59921
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Title
Surface-functionalized Electrospun Polycaprolactone Fiber for Culturing Stem Cell from Human Exfoliated Deciduous Teeth Culture
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Abstract
© 2020, The Korean Fiber Society. Smooth and bead-free polycaprolactone (PCL) fiber with average diameter of 2.8 micron and pore size of 25 micron were spun from 17 % w/w PCL dissolved in a chloroform:methyl alcohol mixture (3:1 by volume) at 20 kV, a fiber collection distance of 15 cm, a nozzle diameter of 0.9 mm, and 2 ml/h for 5 hours. Then, the fiber surface was immobilized by gelatin (GE), coated by hyaluronic acid (HA), and done by both processes to obtain GE-PCL, HA-PCL, and HA-GE-PCL, respectively. The treated fiber was completely wet by water, whereas the PCL fiber was not. GE improved thermal stability, while HA increased the tensile strength and elastic moduli of the fiber. Both GE and HA reduced their elongations at break. Stem cells from human deciduous teeth (SHED) were chosen to study their proliferation on the fiber, which was exponentially in the following order: GE-PCL > HA-GE-PCL > HA-PCL gt; PCL.