Publication: A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene
Submitted Date
Received Date
Accepted Date
Issued Date
2000-01-01
Copyright Date
Announcement No.
Application No.
Patent No.
Valid Date
Resource Type
Edition
Resource Version
Language
File Type
No. of Pages/File Size
ISBN
ISSN
14664879
eISSN
Scopus ID
WOS ID
Pubmed ID
arXiv ID
Call No.
Other identifier(s)
2-s2.0-0034577203
Journal Title
Volume
Issue
item.page.oaire.edition
Start Page
End Page
Access Rights
Access Status
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Physical Location
Bibliographic Citation
Genes and Immunity. Vol.1, No.4 (2000), 293-294
Citation
E. E. Nakayama, C. Wasi, A. Ajisawa, A. Iwamoto, T. Shioda (2000). A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25900.
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene
Alternative Title(s)
Author(s)
Author's Affiliation
Author's E-mail
Editor(s)
Editor's Affiliation
Corresponding Author(s)
Creator(s)
Compiler
Advisor(s)
Illustrator(s)
Applicant(s)
Inventor(s)
Issuer
Assignee
Series
Has Part
Abstract
Interleukin 16 (IL-16) is a chemotactic cytokine which binds to CD4 and affects T cell activation. Here we report a novel single nucleotide polymorphism, T to C, in the promoter region of the IL-16 gene in two distinct Asian populations, Japanese and Thai. This mutation occurs at an allele frequency of approximately 22% and 18%-respectively. Although IL-16 potently suppresses replication of human immunodeficiency virus type 1 (HIV-1), we observed no significant difference in the allele frequency of this polymorphism between HIV-1-infected and non-HIV-1-infected individuals in both Asian populations. Since differential IL-16 levels have been reported to be associated with inflammatory diseases such as systemic lupus erythematosus, atopic dermatitis and allergic asthma, it would be of interest to analyze the allele frequency of this mutation in patients with these autoimmune and allergic diseases.