Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus
Issued Date
2024-01-01
Resource Type
eISSN
19485182
Scopus ID
2-s2.0-85190113258
Journal Title
World Journal of Hepatology
Volume
16
Issue
3
Start Page
366
End Page
378
Rights Holder(s)
SCOPUS
Bibliographic Citation
World Journal of Hepatology Vol.16 No.3 (2024) , 366-378
Suggested Citation
Choochuay K., Kunhapan P., Puangpetch A., Tongsima S., Srisawasdi P., Sobhonslidsuk A., Sungkanuparph S., Biswas M., Sukasem C. Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus. World Journal of Hepatology Vol.16 No.3 (2024) , 366-378. 378. doi:10.4254/wjh.v16.i3.366 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98034
Title
Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus
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Abstract
BACKGROUND The prevalence of metabolic-associated fatty liver disease (MAFLD) is a growing public health issue in people living with human immunodeficiency virus (PLWH). However, the pathophysiology of MAFLD is still unknown, and the role of genetic variables is only now becoming evident. AIM To evaluate the associations of gene-polymorphism-related MAFLD in PLWH. METHODS The study employed transient elastography with a controlled attenuation parameter ≥ 248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand. Candidate single-nucleotide poly-morphisms (SNPs) were genotyped using TaqMan® MGB probe 5' nuclease assays for seven MAFLD-related genes. Statistical analyses included SNP frequency analysis, Fisher's Exact and Chi-square tests, odds ratio calculations, and multivariable logistic regression. RESULTS The G-allele carriers of PNPLA3 (rs738409) exhibited a two-fold rise in MAFLD, increasing by 2.5 times in MAFLD with human immunodeficiency virus infection. The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times (P = 0.001) more significant chance of developing aberrant triglyceride among PLWH. CONCLUSION The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH.