Browsing by Author "Carolyn A. Hutyra"

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    Plasmodium falciparum genetic crosses in a humanized mouse model
    (2015-06-30) Ashley M. Vaughan; Richard S. Pinapati; Ian H. Cheeseman; Nelly Camargo; Matthew Fishbaugher; Lisa A. Checkley; Shalini Nair; Carolyn A. Hutyra; François H. Nosten; Timothy J.C. Anderson; Michael T. Ferdig; Stefan H.I. Kappe; Biomedical Research Institute; University of Notre Dame; Texas Biomedical Research Institute; Mahidol University; University of Washington, Seattle
    © 2015 Nature America, Inc. All rights reserved. Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.