Browsing by Author "Chih Yen Tu"

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    Bidirectional association between asthma and irritable bowel syndrome: Two population-based retrospective cohort studies
    (2016-04-01) Te Chun Shen; Cheng Li Lin; Chang Ching Wei; Chia Hung Chen; Chih Yen Tu; Te Chun Hsia; Chuen Ming Shih; Wu Huei Hsu; Fung Chang Sung; Chia Hung Kao; China Medical University Taichung; China Medical University Hospital Taichung; Mahidol University
    © 2016 Shen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database. Methods: We conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities. Results: The incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. Conclusion: The present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation.
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    Reply from authors: RE: Risk of periodontal disease in patients with asthma: A nationwide population-based retrospective cohort study
    (2018-05-01) Te Chun Shen; Pei Ying Chang; Cheng Li Lin; Chang Ching Wei; Chih Yen Tu; Te Chun Hsia; Chuen Ming Shih; Wu Huei Hsu; Fung Chang Sung; Chia Hung Kao; Asia University Taiwan; China Medical University Hospital Taichung; Mahidol University; China Medical University Taichung
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    Risk of periodontal disease in patients with asthma: A nationwide population-based retrospective cohort study
    (2017-08-01) Te Chun Shen; Pei Ying Chang; Cheng Li Lin; Chang Ching Wei; Chih Yen Tu; Te Chun Hsia; Chuen Ming Shih; Wu Huei Hsu; Fung Chang Sung; Chia Hung Kao; China Medical University Taichung; China Medical University Hospital Taichung; China Medical University Hospital; Mahidol University; Asia University Taiwan
    Background: Studies have reported an association between asthma and oral diseases, including periodontal diseases. The aim of this retrospective study is to investigate risk of periodontal diseases for patients with asthma. Methods: Using the claims data of National Health Insurance of Taiwan and patients without a history of periodontal diseases, 19,206 asthmatic patients, who were newly diagnosed from 2000 through 2010, were identified. For each case, four comparison individuals without history of asthma and periodontal disease were randomly selected from the general population and frequency matched (categorical matched) by sex, age, and year of diagnosis (n = 76,824). Both cohorts were followed to the end of 2011 to monitor occurrence of periodontal diseases. Adjusted hazard ratios (aHRs) of periodontal disease were estimated using Cox proportional hazards regression analysis. Results: Overall incidence of periodontal diseases was 1.18-fold greater in the asthma cohort than in the comparison cohort (P <0.001). Patients with at least three emergency visits annually had an aHR of 55.9 (95% confidence interval [CI] = 50.6 to 61.7) for periodontal diseases compared with those with a mean of less than one visit. Patients with at least three admissions annually also had a similar aHR (51.8) for periodontal disease. In addition, asthmatic patients on inhaled corticosteroid (ICS) therapy had greater aHRs than non-users (aHR = 1.12; 95% CI = 1.03 to 1.23). Conclusions: In the studied population, asthmatic patients are at an elevated risk of developing periodontal diseases. The risk is much greater for those with emergency medical demands or hospital admissions and those on ICS treatment.