Browsing by Author "Fumiaki Nakajima"

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    Both HLA-B*1301 and B*1302 Exist in Asian Populations and Are Associated with Different Haplotypes
    (1995-01-01) Ling Lin; Katsushi Tokunaga; Fumiaki Nakajima; Yoshihide Ishikawa; Kouichi Kashiwase; Hidenori Tanaka; Shoji Kuwata; Elena W. Sideltseva; Tatsuya Akaza; Kenji Tadokoro; Yoichi Shibata; Dasnayanee Chandanayingyong; Takeo Juji; Japanese Red Cross Medical Center; University of Tokyo; Kanagawa Red Cross Blood Center; Immunogenetics Research Centre; Mahidol University
    A B13 split antigen was newly identified with three alloantisera in Japanese, and two B13 split antigens were found in a Thai family. To confirm the variation of B13 and understand the correspondence between the serologic splits and the published B13 alleles, B*1301 and B*1302, we determined the sequences of genes coding for these B13 splits. The common Japanese B13 allele was found to be B*1301, whereas another split antigen was shown to be coded by B*1302. Two B13 variants identified in a Thai individual corresponded to B*1301 and B*1302. Moreover, 57 B13-positive samples from several ethnic groups were examined using the PCR-SSO method. Differing from previous reports, both B*1301 and B*1302 were found in samples from Asian populations. These two alleles were separately associated with different antigens: HLA-B*1301 exhibited a strong association with A2, Cw10, DR12, and DQ7 antigens, whereas HLA-B*1302 was strongly associated with A30, Cw6, DR7, and DQ2 antigens. In addition, applying the PCR-SSCP method, B*1301 and B*1302 could also be simply distinguished from each other. © 1995.