Browsing by Author "Kaewwichai W."

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    Effectiveness of a multimodal strategy to reduce external ventricular drain–associated infection: A quasi-experimental study
    (2024-01-01) Pongkaew C.; Noiphithak R.; Rukskul P.; Yodwisithsak P.; Tantongtip D.; Nimmannitya P.; Punyarat P.; Duangprasert G.; Kaewwichai W.; Songphul S.; Chancharoenrat W.; Jantarathaneewat K.; Chokaouychai C.; Sukhor S.; Apisarnthanarak P.; Camins B.C.; Weber D.J.; Apisarnthanarak A.; Pongkaew C.; Mahidol University
    Background: Infection is a serious complication in neurosurgical patients who undergo external ventricular drain (EVD) insertion. Methods: We conducted a quasi-experimental study in patients who underwent EVD insertion to evaluate the impact of a multi-modal strategy to reduce the incidence of external ventricular drain associated infections (EVDAIs). The study was divided into 2 periods; (1) the pre-intervention period when techniques for EVD insertion and maintenance were up to the discretion of the neurosurgeons and (2) the post-intervention after implementation of a multi-modal strategy (cefazolin antibiotic prophylaxis, preoperative chlorhexidine showers, application of postoperative chlorhexidine-impregnated dressing, limited manipulation of the EVD, and meticulous EVD management). The primary outcome was the incidence rate of EVDAIs; secondary outcomes included in-hospital mortality rate, the hospital length of stay. Results: In total, 135 patients were included. The incidence rate of EVDAIs was significantly reduced in the post-intervention period (5.6 cases/1,000 EVD-days) compared with the pre-intervention period (18.2 cases/1,000 EVD-days; P=0.026). There were no differences in all secondary outcomes analyzed. This multi-modal strategy was associated with high satisfaction among health care personnel. Conclusions: Implementation of a multi-modal strategy was associated with a reduction in the incidence of EVDAIs. This was in line with our goal of promoting a new culture of safety despite being in a resource-limited setting.