Browsing by Author "Katharina Schultz"

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    A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase
    (2015-03-23) Friederike I. Nollmann; Antje K. Heinrich; Alexander O. Brachmann; Christophe Morisseau; Krishnendu Mukherjee; Ángel M. Casanova-Torres; Frederic Strobl; David Kleinhans; Sebastian Kinski; Katharina Schultz; Michael L. Beeton; Marcel Kaiser; Ya Yun Chu; Long Phan Ke; Aunchalee Thanwisai; Kenan A.J. Bozhüyük; Narisara Chantratita; Friedrich Götz; Nick R. Waterfield; Andreas Vilcinskas; Ernst H.K. Stelzer; Heidi Goodrich-Blair; Bruce D. Hammock; Helge B. Bode; Goethe-Universitat Frankfurt am Main; University of California, Davis; Fraunhofer Institute for Molecular Biology and Applied Ecology IME; University of Wisconsin Madison; Cardiff Metropolitan University; Universitat Basel; Universitat Tubingen; Vietnamese Academy of Science and Technology; Naresuan University; Mahidol University; Warwick Medical School
    © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.