Browsing by Author "Lynette Kiers"

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    Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis
    (2013-01-15) Arada Rojana-Udomsart; Chalermchai Mitrpant; Ian James; Campbell Witt; Merrilee Needham; Timothy Day; Lynette Kiers; Alastair Corbett; Patricia Martinez; Steve D. Wilton; Frank L. Mastaglia; University of Western Australia; Yala Hospital; Mahidol University; Royal Perth Hospital; Royal North Shore Hospital; University of Sydney Faculty of Medicine; Royal Melbourne Hospital; University of Melbourne; Concord Repatriation General Hospital
    We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM. © 2012 Elsevier B.V.